Protein Alignment alpha-Est8 and CEL

DIOPT Version :10

• Sequence 1: NP_524259.2
• Gene: alpha-Est8 / 40899
• FlyBaseID: FBgn0015576
• Length: 574
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 170/578 - (29%)
• Similarity: 253/578 - (43%)
• Gaps: 111/578 - (19%)

  Fly    40 GKVKGV-KWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPE-H--WSDVKRCTHVRAKPCQVNI 100
            |.|:|| |...:.|::...|:|||||.|.      ||...|: |  |....:..:.:.:..|..|
Human    31 GFVEGVNKKLGLLGDSVDIFKGIPFAAPT------KALENPQPHPGWQGTLKAKNFKKRCLQATI 89

  Fly   101 VLKQVQGSEDCLYLNVYTRE--LHPHRPLPVLVWIYGGGFQMGEA------SRDLYSPDYIMME- 156
            ......|.|||||||::..:  ....|.|||::|||||.|.||..      :..||..:.|...
Human    90 TQDSTYGDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDGEEIATRG 154

  Fly   157 HVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDNITVFGESAGG 221
            :|::|..:||:|.|||||..|..|  |||.||:||.||:.|||||...|||||:|||:|||||||
Human   155 NVIVVTFNYRVGPLGFLSTGDANL--PGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFGESAGG 217

  Fly   222 ASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGY-TGDANDRDIFAHLKK 285
            ||.....|:...|||..:.|..||.||:||......:.|..::|:..|. .|||      |.:.:
Human   218 ASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGDA------ARMAQ 276

  Fly   286 CKASSMLKVAED-IITMEER-------HQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDCWGNS 342
            |     |||.:. .:|:..:       :..|....|.|.|:...     ||..|:.:    :.|:
Human   277 C-----LKVTDPRALTLAYKVPLAGLEYPMLHYVGFVPVIDGDF-----IPADPINL----YANA 327

  Fly   343 --IPMVIGGNSFEGLLM----FPEVNKWPELLCQLGDCENLAPQDAHVDEQQRKAFGKKVRELYF 401
              |..:.|.|:.:|.:.    .|.:||                .:..|.|:.   |.|.|.|...
Human   328 ADIDYIAGTNNMDGHIFASIDMPAINK----------------GNKKVTEED---FYKLVSEFTI 373

  Fly   402 GDRTPGRKTILE-YSDLFSYKYFWHGIHRTL--------------LSRAHH---APLAPTFLYRF 448
            .....|.||..: |::.::.........:|:              ::.|.|   |..|.|:.|.|
Human   374 TKGLRGAKTTFDVYTESWAQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAYLF 438

  Fly   449 DFDSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGD 513
            ...|:    |.:..   |..|..||||:.|:|....|.....|..:....|.:::...:||.:||
Human   439 SHPSR----MPVYP---KWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTGD 496

  Fly   514 PNIPMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDLPEAEK---LRLWDCIY 568
            ||:     .:...|. .|.|.:.::..:  |.|:..:....:..:.:   ||.|...|
Human   497 PNM-----GDSAVPT-HWEPYTTENSGY--LEITKKMGSSSMKRSLRTNFLRYWTLTY 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	34..564	CDD:395084	168/572 (29%)
CEL	NP_001798.3	Heparin-binding	21..121		31/95 (33%)
		COesterase	26..542	CDD:395084	168/572 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
		Mucin-like	584..677	CDD:464997
		Mucin-like	639..731	CDD:464997