DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces2a

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	582	Identity:	167/582 - (28%)
Similarity:	259/582 - (44%)	Gaps:	108/582 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 QRLRSNDKV--IADTVYGKVKG----VKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPVEPEHWS 83
            |.:...|..  |.:|..|:|:|    ||...   :..::|.||||||||||.|||..|.:||.||
Mouse    22 QHVHGQDSASPIRNTHRGQVRGSFVHVKDTK---SGVHAFLGIPFAKPPVGLLRFAPPEDPEPWS 83

  Fly    84 DVKRCTHVRAKPCQ-----------VNIVLKQVQGSEDCLYLNVYTRELHPHR--PLPVLVWIYG 135
            .|:..|...|...|           :|::|..:..||||||||:|| ..|...  .|||:|||:|
Mouse    84 GVRDGTSQPAMCLQPDIMNLEDAKEMNLILPPISMSEDCLYLNIYT-PTHAQEGSNLPVMVWIHG 147

  Fly   136 GGFQMGEASRDLYSPDYIMMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKR 200
            ||..:|.||.:..| .....|.:|:|.|.||||.|||.|..|:.  ..||.|..|||.|||||::
Mouse   148 GGLVVGSASMNDVS-KLAATEEIVIVAIQYRLGVLGFFSTGDQH--ARGNWGYLDQVAALRWVQK 209

  Fly   201 NCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLA 265
            |..:|||:.|.:|:||.||||.|....:|:..:|||||..|:.||.||.|...:.|.......:|
Mouse   210 NIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLISDTSEVVYKTVA 274

  Fly   266 QATGYTGDANDRDIFAHLKKCKASSMLKVAEDIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKS 330
            ..:|.  :|.|.:...|..:.|:.      ::|:.:.:..:.:          |.:.....:||.
Mouse   275 NLSGC--EATDSEALIHCLRAKSK------QEILAINQVFKMI----------PAVVDGEFLPKH 321

  Fly   331 PLEMMRDCWGNSIPMVIGGNSFE---GLLMFPEVN---------KWPELLCQLGDCENLAPQDAH 383
            |.|::.....:.:|.:||.|:.|   |:.||..::         ..|.:|........|.|:.:|
Mouse   322 PQELLTSMDFHPVPSIIGVNTDECGWGVPMFMGLDHIIKNITRETLPAVLKNTAARMMLPPECSH 386

  Fly   384 VDEQQRKAFGKKVRELYFGDRTPGRKTILEYSDLF-SYKYFWHGIHRTLLSRAHHAPLAPTFLYR 447
            :           :.|.|.||.........::.::. .:.:....:......|:.    ||.:.|.
Mouse   387 L-----------LVEEYMGDTEDPETLQAQFREMLGDFMFVIPALQVAHFQRSQ----APVYFYE 436

  Fly   448 FDFDS---KHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMV-VHF 508
            |...|   ||.....:        ...|.||::::|.:.........|.|.:.:||::... .:|
Mouse   437 FQHLSSFIKHVRPSHV--------KADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMMMKYWANF 493

  Fly   509 AISGDPNI------PMVCQDEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLW 564
            |.:|:||.      |::..||:      :|.:.....|.:.|            :|.:|:.|
Mouse   494 ARNGNPNSEGLPSWPVLDHDEQ------YLQLDTQPAVGRAL------------KARRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	165/576 (29%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	50/106 (47%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	164/572 (29%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	50/106 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832748
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750