DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and bchel

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	XP_002937472.3	Gene:	bchel / 100135377	XenbaseID:	XB-GENE-5842192	Length:	559	Species:	Xenopus tropicalis

Alignment Length:	615	Identity:	157/615 - (25%)
Similarity:	261/615 - (42%)	Gaps:	139/615 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IALNYVKFKTNQQRLRSNDKVIADTVYGKVKGVKWQSIYGNNYYSFEGIPFAKPPVGELRFKAPV 77
            :.::::...||     :..:.|.:...|||.|:. .|:......::.|||:.:||.|.||||...
Frog    17 LLMSFLILSTN-----AGHENIVEVKQGKVSGIN-LSVKSGYVTAYLGIPYGEPPTGRLRFKKTE 75

  Fly    78 EPEHWSDVKRCTHVRAKPCQVN------------IVLKQVQGSEDCLYLNVYTRELHPHRP--LP 128
            :.:.|..|.:.... .|.|..|            :.|...:.|||||:|||:   :.|.:|  ..
Frog    76 QRKPWHGVLKADKF-GKSCFQNRENKFAEFPGTEMFLVNNEMSEDCLHLNVW---VPPSKPKDAH 136

  Fly   129 VLVWIYGGGFQMGEASRDLYSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQV 192
            |:|:|:||||:.|..|.|:|....: ..|:|::|.::||:||.|||:|...: |.||||||.||.
Frog   137 VMVFIHGGGFESGTTSLDIYDGSVLAYAENVIVVSMNYRVGAFGFLALPGHK-DAPGNAGLFDQR 200

  Fly   193 MALRWVKRNCQFFGGDPDNITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTH 257
            :||:|:..|...|||:||.:|:||.|||.||..:.:::.::...:::.|:.|||..:.||.
Frog   201 LALQWINENIAAFGGNPDRVTIFGHSAGAASVGFHLISPKSYPYYNRAIVQSGSGTSNWAL---- 261

  Fly   258 INWPYRLAQATGYTGDANDRDIFAHLKKCKASSMLKVAED-IIT--MEERHQRLT---------- 309
                           ::.:|.....||..:.....:..:| |||  :.|..:.||
Frog   262 ---------------NSEERAKRLALKLAEVLECPQTDDDAIITCLLNEDPKHLTEKQLLAKEPY 311

  Fly   310 -MFSFGPTIE-PYL--TPHCVIPKSP------LEMMRDCWGNSIPMVIGGNSFE----------G 354
             :..|.|.:: .:|  .|..|:.:|.      |.:.:|. ||...: ||...|.          .
Frog   312 ALTQFLPIVDHDFLVDVPENVLGQSMKRTDILLGITKDD-GNPFTL-IGSTDFNIQTESSISSAE 374

  Fly   355 LL-----MFPEVNKW--PELLCQLGDCENLAPQDAHVDEQQRKAFGKKVRELYFGDRTPG--RKT 410
            ||     .||.....  ..:|.|..|.|     |.:..|:.|:|....:|:.||.....|  |..
Frog   375 LLERLKRFFPSAGDLGIQSILLQYKDWE-----DVNNGEKNRQAMELILRDYYFACPVKGFARYA 434

  Fly   411 ILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDFDSKHFNIMRIITCGRKVRGTCHADD 475
            :...:::|.|:|.         .|:.:.|. |.::                       |..|..:
Frog   435 VEHQNNVFFYEYD---------HRSSNDPW-PEWM-----------------------GALHGAE 466

  Fly   476 LSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPNIPMVCQDEKEQPRG-AWLPISKDDK 539
            |..||......|.:...:|....||::.:..:||.:|.||:        |...| .|...|..|:
Frog   467 LPMLFGKPFINKGRYTRSELLFSKRIMKLWANFARTGSPNV--------EAEDGFVWPQYSLKDE 523

  Fly   540 VFQCLNIS-HDVHVIDLPEAEKLRLWDCIY 568
            .:..|.:: .:||  .:......:.|:..:
Frog   524 KYAVLKLNGSEVH--QMLSMRNCQFWNFFF 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	154/593 (26%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	48/107 (45%)
bchel	XP_002937472.3	COesterase	31..547	CDD:395084	154/590 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910