DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est8 and Ces1f

DIOPT Version :9

Sequence 1:	NP_524259.2	Gene:	alpha-Est8 / 40899	FlyBaseID:	FBgn0015576	Length:	574	Species:	Drosophila melanogaster
Sequence 2:	NP_001096829.2	Gene:	Ces1f / 100125372	RGDID:	1642419	Length:	561	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	175/573 - (30%)
Similarity:	260/573 - (45%)	Gaps:	94/573 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 IADTVYGKVKGVKWQSIYG--NNYYSFEGIPFAKPPVGELRFKAPVEPEHWSDVKR-------CT 89
            :.||..|||.| |:.|:.|  .:...|.|:||||||:|.|||..|...|.||.||.       |:
  Rat    25 VVDTTKGKVLG-KYVSLEGVTQSVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTTYPPMCS 88

  Fly    90 HVRAKPCQVNIVLK------QVQGSEDCLYLNVYT-RELHPHRPLPVLVWIYGGGFQMGEASRDL 147
            ...||..::|.:|.      .::.||||||||:|| .:...:..|||:|||:|||..:|.||  .
  Rat    89 QDAAKGQRMNDLLTNRKEKIHLEFSEDCLYLNIYTPADFTKNSRLPVMVWIHGGGMTLGGAS--T 151

  Fly   148 YSPDYI-MMEHVVLVVISYRLGALGFLSLADEELDVPGNAGLKDQVMALRWVKRNCQFFGGDPDN 211
            |....: ..|:||:|.|.||||..||.|..||.  ..||.|..|||.||.||:.|...|||||.:
  Rat   152 YDGRVLSAYENVVVVAIQYRLGIWGFFSTGDEH--SRGNWGHLDQVAALHWVQDNIANFGGDPGS 214

  Fly   212 ITVFGESAGGASTHYMMLTDQAKGLFHKTIIMSGSALAPWAQTPTHINWPYRLAQATGYTGDAND 276
            :|:|||||||.|...::|:...|.|||:.|..||....|...|........::|...|.  :...
  Rat   215 VTIFGESAGGFSVSVLVLSPLTKNLFHRAISESGVVFLPGLLTKDVRPAAKQIADMAGC--ETTT 277

  Fly   277 RDIFAH-LKKCKASSMLKVAE--DIITMEERHQRLTMFSFGPTIEPYLTPHCVIPKSPLEMMRDC 338
            ..|..| |::.....:|::.:  ::|.:..:......:.|..|:    ..:.|:||.|.|::.:.
  Rat   278 SAIIVHCLRQKTEEELLEIMKKMNLIKLSSQRDNKESYHFLSTV----VDNVVLPKDPKEILAEK 338

  Fly   339 WGNSIPMVIGGNSFE-GLLMFPEVNKWPELLCQLGDCENLAPQDAHVDEQQRKAFGKKVRELY-- 400
            ..|::|.::|.|..| |.|:       |.::       ...|.|..:|::......:|...||
  Rat   339 NFNTVPYIVGINKQECGWLL-------PTMM-------GFVPADVELDKKMAITLLEKFASLYGI 389

  Fly   401 ---------------FGDRTPGRKTILEYSDLFSYKYFWHGIHRTLLSRAHHAPLAPTFLYRFDF 450
                           ..|....|..||.:....|:     .|...::||.|....|||::|.:.:
  Rat   390 PEDIIPVAIEKYRKGSDDSIKIRDGILAFIGDVSF-----SIPSVMVSRDHRDAGAPTYMYEYQY 449

  Fly   451 DSKHFNIMRIITCGRKVRGTCHADDLSYLFYNAAAKKLKRRTAEFKTIKRLVSMVVHFAISGDPN 515
            .....:..|    .:.|.|. ||||| |..:.|...:......|.|..|.::....:||.:|:||
  Rat   450 YPSFSSPQR----PKHVVGD-HADDL-YSVFGAPILRDGASEEEIKLSKMVMKFWANFARNGNPN 508

  Fly   516 ---IPMVCQ-DEKEQPRGAWLPISKDDKVFQCLNISHDVHVIDLPEAEKLRLW 564
               :|...| |:||:    :|.|....:..|.|            :||::..|
  Rat   509 GRGLPHWPQYDQKEE----YLQIGATTQQSQRL------------KAEEVAFW 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est8	NP_524259.2	COesterase	29..564	CDD:278561	174/571 (30%)
alpha-Est8	NP_524259.2	Aes	<116..>221	CDD:223730	51/106 (48%)
Ces1f	NP_001096829.2	COesterase	24..545	CDD:278561	174/571 (30%)
		Aes	<121..>234	CDD:223730	55/116 (47%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336511
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm44890
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740