Protein Alignment alpha-Est9 and CES2

DIOPT Version :9

• Sequence 1: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 585
• Identity: 173/585 - (29%)
• Similarity: 256/585 - (43%)
• Gaps: 144/585 - (24%)

  Fly    34 VSTTY-----GPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTS---- 89
            :.||:     |.:..||..:...|::..   |||||||:|.||:..|:|||.|:.||..|:
Human    33 IRTTHTGQVLGSLVHVKGANAGVQTFLG---IPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAM 94

  Fly    90 --QGPKPLQKHFV--FEMT----DGSEDCLYLNVYT-KNLYPTKPMPVMVWIYGGGFQFGEASRE 145
              |....::..|:  |.||    ..|||||||::|| .:.:....:||||||:||...||.||
Human    95 CLQDLTAVESEFLSQFNMTFPSDSMSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMAS-- 157

  Fly   146 CYSPDYLLR-EDVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLK 206
            .|....|.. |:|||:.|.||||.||   |.|     ||                  ..||.|..
Human   158 LYDGSMLAALENVVVVIIQYRLGVLGFFSTGD-----KH------------------ATGNWGYL 199

  Fly   207 DQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVT 271
            |||.|||||:.|.:.|||:...:||||:|||..||..::::..:.||||.||..||..|.|..:
Human   200 DQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLFHGAIMESGVALLPGLI- 263

  Fly   272 PQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIK---ANGELC--IDEE----------KK 321
                                          |..:::|.   ||...|  :|.|          |:
Human   264 ------------------------------ASSADVISTVVANLSACDQVDSEALVGCLRGKSKE 298

  Fly   322 ERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNE-GLLLYSETKTNPKCLNE 385
            |.:..:....:.|.|.....:|:.|.|::.:|....:|.|:|..:|| |.|:       ||.:..
Human   299 EILAINKPFKMIPGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLI-------PKVMRI 356

  Fly   386 LDDCRFVVPIELNMDRESA------------LCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHE 438
            .|       .:..||||::            |...:||.||:.|.||.........::.:|::..
Human   357 YD-------TQKEMDREASQAALQKMLTLLMLPPTFGDLLREEYIGDNGDPQTLQAQFQEMMADS 414

  Fly   439 YFWFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLAR 503
            .|..|..:  ::..|.:| ||.|.|.|........::|     .......|||:|.::|.:....
Human   415 MFVIPALQ--VAHFQCSR-APVYFYEFQHQPSWLKNIR-----PPHMKADHGDELPFVFRSFFGG 471

  Fly   504 KLKNHTREYKCIER-LVGLWTHFAACGNPN---------FDPEQEDLWQPVDPA---AVEKHQLK 555
            .....|.|.:.:.| ::..|.:||..||||         ||.|::.|...:.||   |::.|:|:
Human   472 NYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQ 536

  Fly   556  555
            Human   537  536

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	172/583 (30%)
		Aes	<115..>237	CDD:223730	51/126 (40%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	173/585 (30%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142695
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790