DRSC/TRiP Functional Genomics Resources

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Protein Alignment alpha-Est9 and TG

DIOPT Version :10

Sequence 1:NP_731165.2 Gene:alpha-Est9 / 40897 FlyBaseID:FBgn0015577 Length:587 Species:Drosophila melanogaster
Sequence 2:NP_003226.4 Gene:TG / 7038 HGNCID:11764 Length:2768 Species:Homo sapiens


Alignment Length:562 Identity:131/562 - (23%)
Similarity:226/562 - (40%) Gaps:133/562 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 YRTSEKTVVSTTYGPIKGVKRKSIYGQSYFSFER---IPFAKPPVGELRYKAPQPPEVWT----- 82
            |..|..:|..:|:|.:.|..:....|.|:...::   :|:|.||:.|.|::||:|.. ||     
Human  2194 YEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDA 2257

  Fly    83 --EVRSCTSQGPKPLQKHFVFEMTDGSEDCLYLNVY-TKNLYPTKPMPVMVWIYGGGFQFGEASR 144
              ...||...|.:......|      |||||||||: .:|:.|...:.|        |......|
Human  2258 SKPRASCWQPGTRTSTSPGV------SEDCLYLNVFIPQNVAPNASVLV--------FFHNTMDR 2308

  Fly   145 E------CYSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGN 202
            |      .....:|.. .:::|::.:||:|             :|     |||.....|  |.||
Human  2309 EESEGWPAIDGSFLAAVGNLIVVTASYRVG-------------VF-----GFLSSGSGE--VSGN 2353

  Fly   203 AGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGS--ASVHYMMITEQTHGLFHKAICMSGNTL 265
            .||.|||.||.||:.:...||||...:::..|..|:  ||:|.:........||.:|:.|.|:.|
Human  2354 WGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSAL 2418

  Fly   266 SPWAVTPQRNWPYRLAVQA-GYAGE-----NNTRDVWEFLK-------NAKGSEIIKANGELCID 317
            ||.||....    |...|| ..|.|     :::::|...|:       |...::::..:|..   
Human  2419 SPAAVISHE----RAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPF--- 2476

  Fly   318 EEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKC 382
                    ..:||||:    .|.:.......:.|:.|. .:.|:||...::||:      ...|.
Human  2477 --------HYWGPVID----GHFLREPPARALKRSLWV-EVDLLIGSSQDDGLI------NRAKA 2522

  Fly   383 LNELDDCR--------FVVPIELNMDRESALCREYGDQLRQCYYG--DKTPSLDTLHEYLQMVSH 437
            :.:.::.|        |...::.::..|.:..|.  :.....||.  ..|....:....|:..:.
Human  2523 VKQFEESRGRTSSKTAFYQALQNSLGGEDSDARV--EAAATWYYSLEHSTDDYASFSRALENATR 2585

  Fly   438 EYFWF-PIYRTVLSRLQYARSAPTYLYRFDFDSKHFNH--LRILSCGKKVRGTCHGDDLSYL--- 496
            :||.. ||.....:..:.|| ...::|.   ..:::.|  |.:|:            |:.:.   
Human  2586 DYFIICPIIDMASAWAKRAR-GNVFMYH---APENYGHGSLELLA------------DVQFALGL 2634

  Fly   497 -FYNSLARKLKNHTREYKCIE-RLVGLWTHFAACGNPNFDPE 536
             ||.:...:.   :.|.|.:. :::..::||...||||:..|
Human  2635 PFYPAYEGQF---SLEEKSLSLKIMQYFSHFIRSGNPNYPYE 2673

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
alpha-Est9NP_731165.2 COesterase 32..577 CDD:395084 129/556 (23%)
TGNP_003226.4 TY 33..92 CDD:238114
TY 95..160 CDD:238114
TY 300..358 CDD:238114
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..545
Thyroglobulin_1 599..658 CDD:459665
Thyroglobulin_1 662..724 CDD:459665
TY 730..>776 CDD:469630
TY <892..922 CDD:469630
TY 1004..1073 CDD:238114
TY 1077..1145 CDD:238114
TY 1149..1210 CDD:238114
Type II. /evidence=ECO:0000269|PubMed:8797845 1456..1469
Ephrin_rec_like 1465..1510 CDD:429604
Type II. /evidence=ECO:0000269|PubMed:8797845 1470..1486
Type II. /evidence=ECO:0000269|PubMed:8797845 1487..1503
TY 1520..1567 CDD:214561
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1603..1723
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1724..1892
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 1893..1995
Type IIIB. /evidence=ECO:0000269|PubMed:8797845 1996..2129
Type IIIA. /evidence=ECO:0000269|PubMed:8797845 2130..2187
Cholinesterase-like (ChEL). /evidence=ECO:0000250|UniProtKB:O08710 2188..2768 131/562 (23%)
COesterase 2197..2718 CDD:395084 130/559 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2727..2768
Blue background indicates that the domain is not in the aligned region.

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