DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and TG

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	562	Identity:	131/562 - (23%)
Similarity:	226/562 - (40%)	Gaps:	133/562 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 YRTSEKTVVSTTYGPIKGVKRKSIYGQSYFSFER---IPFAKPPVGELRYKAPQPPEVWT----- 82
            |..|..:|..:|:|.:.|..:....|.|:...::   :|:|.||:.|.|::||:|.. ||
Human  2194 YEASVPSVPISTHGRLLGRSQAIQVGTSWKQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDA 2257

  Fly    83 --EVRSCTSQGPKPLQKHFVFEMTDGSEDCLYLNVY-TKNLYPTKPMPVMVWIYGGGFQFGEASR 144
              ...||...|.:......|      |||||||||: .:|:.|...:.|        |......|
Human  2258 SKPRASCWQPGTRTSTSPGV------SEDCLYLNVFIPQNVAPNASVLV--------FFHNTMDR 2308

  Fly   145 E------CYSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGN 202
            |      .....:|.. .:::|::.:||:|             :|     |||.....|  |.||
Human  2309 EESEGWPAIDGSFLAAVGNLIVVTASYRVG-------------VF-----GFLSSGSGE--VSGN 2353

  Fly   203 AGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGS--ASVHYMMITEQTHGLFHKAICMSGNTL 265
            .||.|||.||.||:.:...||||...:::..|..|:  ||:|.:........||.:|:.|.|:.|
Human  2354 WGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTARATNSQLFRRAVLMGGSAL 2418

  Fly   266 SPWAVTPQRNWPYRLAVQA-GYAGE-----NNTRDVWEFLK-------NAKGSEIIKANGELCID 317
            ||.||....    |...|| ..|.|     :::::|...|:       |...::::..:|..
Human  2419 SPAAVISHE----RAQQQAIALAKEVSCPMSSSQEVVSCLRQKPANVLNDAQTKLLAVSGPF--- 2476

  Fly   318 EEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKC 382
                    ..:||||:    .|.:.......:.|:.|. .:.|:||...::||:      ...|.
Human  2477 --------HYWGPVID----GHFLREPPARALKRSLWV-EVDLLIGSSQDDGLI------NRAKA 2522

  Fly   383 LNELDDCR--------FVVPIELNMDRESALCREYGDQLRQCYYG--DKTPSLDTLHEYLQMVSH 437
            :.:.::.|        |...::.::..|.:..|.  :.....||.  ..|....:....|:..:.
Human  2523 VKQFEESRGRTSSKTAFYQALQNSLGGEDSDARV--EAAATWYYSLEHSTDDYASFSRALENATR 2585

  Fly   438 EYFWF-PIYRTVLSRLQYARSAPTYLYRFDFDSKHFNH--LRILSCGKKVRGTCHGDDLSYL--- 496
            :||.. ||.....:..:.|| ...::|.   ..:::.|  |.:|:            |:.:.
Human  2586 DYFIICPIIDMASAWAKRAR-GNVFMYH---APENYGHGSLELLA------------DVQFALGL 2634

  Fly   497 -FYNSLARKLKNHTREYKCIE-RLVGLWTHFAACGNPNFDPE 536
             ||.:...:.   :.|.|.:. :::..::||...||||:..|
Human  2635 PFYPAYEGQF---SLEEKSLSLKIMQYFSHFIRSGNPNYPYE 2673

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	129/555 (23%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	34/129 (26%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		131/562 (23%)
		COesterase	2197..2718	CDD:395084	130/559 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142808
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.840