DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and NLGN2

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_065846.1	Gene:	NLGN2 / 57555	HGNCID:	14290	Length:	835	Species:	Homo sapiens

Alignment Length:	630	Identity:	165/630 - (26%)
Similarity:	256/630 - (40%)	Gaps:	171/630 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVSTTYGPIKGVKRK---SIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPK- 93
            ||:|.||.::||:|:   .|.| ....|..:|:|.||:|..|::.|:.|..|..||:.|:..|.
Human    43 VVNTAYGRVRGVRRELNNEILG-PVVQFLGVPYATPPLGARRFQPPEAPASWPGVRNATTLPPAC 106

  Fly    94 PLQKHFVFE-------MTDG-----------SEDCLYLNVYTKNLYPTK--PM------------ 126
            |...|....       .||.           ||||||||:|.    ||:  |:
Human   107 PQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYV----PTEDGPLTKKRDEATLNPP 167

  Fly   127 ----------PVMVWIYGGGFQFGEASRECYSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKH 180
                      |||::::||.:.  |.:...:....|.. .:|:|.::|||||.|
Human   168 DTDIRDPGKKPVMLFLHGGSYM--EGTGNMFDGSVLAAYGNVIVATLNYRLGVL----------- 219

  Fly   181 IFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMM 245
                   |||...|..  ..||.||.||:.||||:..|.:.||||...|||||..||::.|:.::
Human   220 -------GFLSTGDQA--AKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLI 275

  Fly   246 ITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYR----LAVQAGYAGENNTRDVWEFLKNAKGSE 306
            ::..:.|||.|||..||..:|.|:|..|   |.:    ||.:.|...|::...| |.|:.
Human   276 LSHHSEGLFQKAIAQSGTAISSWSVNYQ---PLKYTRLLAAKVGCDREDSAEAV-ECLRR----- 331

  Fly   307 IIKANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLL 371
              |.:.||...:.:..|...:||||::     ..|||..|..:|:.....|..::||....|||.
Human   332 --KPSRELVDQDVQPARYHIAFGPVVD-----GDVVPDDPEILMQQGEFLNYDMLIGVNQGEGLK 389

  Fly   372 LYSETKTNPK---------CLNELDDCRFVVPIELNMDRESA-------LCREYGDQLRQCYYGD 420
            ...::..:..         .::...|..:..|...::.||:.       ..|:.|:..|:...
Human   390 FVEDSAESEDGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLL-- 452

  Fly   421 KTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVR 485
               :|.|.|:::.         |...|......|  .:|.|.|.|      ::|     |..:.|
Human   453 ---ALFTDHQWVA---------PAVATAKLHADY--QSPVYFYTF------YHH-----CQAEGR 492

  Fly   486 ----GTCHGDDLSYLFYNSLARKLK----NHTREYKCIERLV-GLWTHFAACGNPNFDPEQEDLW 541
                ...|||:|.|:|...:.....    |.::....:..:| ..||:||..|:||
Human   493 PEWADAAHGDELPYVFGVPMVGATDLFPCNFSKNDVMLSAVVMTYWTNFAKTGDPN--------- 548

  Fly   542 QPVDPAAVEKHQLKCLNISDELKVIDV-PDLKKLMVWESFFRRDE 585
            |||               ..:.|.|.. |:..:.:||..|..:::
Human   549 QPV---------------PQDTKFIHTKPNRFEEVVWSKFNSKEK 578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	159/597 (27%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	43/146 (29%)
NLGN2	NP_065846.1	COesterase	41..601	CDD:278561	165/630 (26%)
		Aes	<170..>268	CDD:223730	40/119 (34%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	623..668
		Required for interaction with LHFPL4. /evidence=ECO:0000250\|UniProtKB:Q69ZK9	678..698
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	790..835
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142791
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740