DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and cel.2

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001020344.2	Gene:	cel.2 / 565117	ZFINID:	ZDB-GENE-061110-10	Length:	551	Species:	Danio rerio

Alignment Length:	576	Identity:	163/576 - (28%)
Similarity:	245/576 - (42%)	Gaps:	86/576 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VSTTYGPIKGVKRKSIYGQSYFS-FERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQK 97
            |.|..|.::| |..|:....|.. |:.||||.|| |.|:...|.|.  |..|...|....:.:|.
Zfish    26 VLTEGGMVQG-KSHSVGLLRYMDVFKGIPFAAPP-GRLQKPVPHPG--WEGVLKATEYSKRCIQL 86

  Fly    98 HFVFEMTDGSEDCLYLNVYT-KNLYPTKPMPVMVWIYGGGFQFGEASRECYSPDYLL-------R 154
            :.:...|.|||||||||::. :....:..:||||:||||||..|......:..:||.       |
Zfish    87 NLLQTDTMGSEDCLYLNIWVPQGKTVSYNLPVMVFIYGGGFLLGGGQGANFLDNYLYDGEEIADR 151

  Fly   155 EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANC 219
            .:|:|::.|||:|.:                  |||...|  .|.|||.||.||..|:.||..|.
Zfish   152 GNVIVVTFNYRVGSM------------------GFLSTGD--ADAPGNYGLWDQHAAISWVHRNI 196

  Fly   220 SRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQ-RNWPYRLAVQ 283
            ..|||:..||||||:||||.||::.:|:.:..||..:||..||..|.|||:... |.:...:|.:
Zfish   197 KAFGGNPDNITIFGESAGSTSVNFQIISPKNKGLIRRAISQSGVALCPWAINRNPRKFAEEIAKK 261

  Fly   284 AGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERI--GFSFGPVIEPYVTSHCVVPKKP 346
            .|...::.   :...|:......:..| |::.:.....|.|  .....|||:     ...:|.:|
Zfish   262 VGCPTDSG---MVACLRRTDPKAVTLA-GKVRLATSATEPIVHNLYLSPVID-----GDFIPDEP 317

  Fly   347 IEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNEL----DDCRFVVPIELNMDRES---- 403
            ..:...|  .:|..|.|....:|.:.  .|...|...|.|    ::....:...|:.||..
Zfish   318 DTLFGNA--ADIDYIAGVNDMDGHIF--ATLDIPSINNALATTTEEEVQALATALSKDRGQDAGI 378

  Fly   404 ALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFD 468
            |..:||     ...:|.|....|.....::|.:...|..|....:......|:||.||.|.|...
Zfish   379 ATFQEY-----TVNWGSKPNKEDIKKTVVEMETDYIFLVPTQTALYLHSDNAKSARTYSYLFSES 438

  Fly   469 SKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAACGNPNF 533
            |:       :.......|..|.|:|.|:|.......|....|.....:.::..||:||..||||.
Zfish   439 SR-------IPIFPLWMGADHADELQYVFGKPFTTPLGYFPRHRDVSKYMIAYWTNFAQTGNPNT 496

  Fly   534 DPEQEDLWQP--VDPAAVEKHQLKCLNISDELKVIDVPDLKKLM------VWESFF 581
            ...:..:..|  .:|.    ||.  |:|:::   |:...:||::      .|.:.|
Zfish   497 GESKVPVTWPEFSNPG----HQY--LDINNK---INTNSVKKMLRTRLVYYWTTVF 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	156/542 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	46/129 (36%)
cel.2	NP_001020344.2	COesterase	26..539	CDD:306613	161/570 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575583
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.750