DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and ces2b

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_021326380.1	Gene:	ces2b / 561967	ZFINID:	ZDB-GENE-041014-96	Length:	1611	Species:	Danio rerio

Alignment Length:	567	Identity:	171/567 - (30%)
Similarity:	245/567 - (43%)	Gaps:	99/567 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QRRYRTSEKTVVSTTYGPIKGVKRKSIYGQS--YFSFERIPFAKPPVGELRYKAPQPPEVWTEVR 85
            |...:..:..::.|..|.:||::.|: .|:.  ..|:..|||||||||.||...|||.|.|..||
Zfish    20 QNSVKAEDGPILQTNSGALKGLQMKA-RGKDTVIHSYLGIPFAKPPVGPLRLAPPQPAEKWEGVR 83

  Fly    86 SCTSQGPKPLQKHFVFE-----------MTDGSEDCLYLNVYTKNLYPTKP-----MPVMVWIYG 134
            ..|.|....||...:.|           |.|.|||||||||||    |:||     :||||||:|
Zfish    84 DATKQPLMCLQDRQLVEDLVANLSAKVDMVDSSEDCLYLNVYT----PSKPGRNDKLPVMVWIHG 144

  Fly   135 GGFQFGEASRECYSPDYLLR-EDVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDP 195
            |||....||  .:....|.. :||||:.|.||||.||   |.|:
Zfish   145 GGFTTCSAS--LFDGHVLAAYQDVVVVVIQYRLGLLGFFSTGDE--------------------- 186

  Fly   196 ELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICM 260
              :.|||.||.|||.||:||:.|...||||..::||||:|||..||...:::..:..|||:||..
Zfish   187 --NAPGNYGLLDQVAALQWVQENIHSFGGDPGSVTIFGESAGGISVSLHVLSPLSANLFHRAIAE 249

  Fly   261 SGNTLSPWAVTPQRNWPYRLAV-QAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERI 324
            || |.:..|:......|...|: .|.....::|:.:.:.|......||:|...|..:
Zfish   250 SG-TAAMEAIMNVNPLPIAQAIGNASGCDISSTKKIVDCLMQKSEVEILKITMENPL-------- 305

  Fly   325 GFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDC 389
             |.||..|:..     .:|:...|:.::...|.:||:.|...:|...:.......|..:|.| |.
Zfish   306 -FRFGVTIDGQ-----FLPRPAAELFQSQQFNKVPLMTGVTDDEIGFVLPNYLLPPDWINGL-DL 363

  Fly   390 RFVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQY 454
            ..::|: |.:...:...:...:.|...|.|.....:.....:.:|:....|..|..:|.    .|
Zfish   364 ESILPL-LTVFNPALQDQSVLELLLNEYLGTSPDRIRIRDGFREMLGDFMFNIPARQTA----SY 423

  Fly   455 AR--SAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYN-------SLARKLKNHTR 510
            .|  .||.|:|.|..........|     ....|:.|||::.::|..       .:|..|.:  .
Zfish   424 HRDAGAPVYVYEFRHPPSVLQRKR-----PSFSGSDHGDEIVFVFGYCFSEGPIGMAENLSD--E 481

  Fly   511 EYKCIERLVGLWTHFAACGNPN---------FDPEQEDLWQPVDPAA 548
            |.:.....:..|.:||..||||         |..|.|.|...:||.|
Zfish   482 EDELCRTTMAYWGNFAHTGNPNGPGLTSWPEFGDEAEYLSIGLDPKA 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	170/557 (31%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	54/130 (42%)
ces2b	XP_021326380.1	COesterase	27..539	CDD:306613	170/560 (30%)
		COesterase	553..1065	CDD:306613
		COesterase	1079..1592	CDD:306613
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910