DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces2h

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001037723.1	Gene:	Ces2h / 498940	RGDID:	1560889	Length:	558	Species:	Rattus norvegicus

Alignment Length:	632	Identity:	173/632 - (27%)
Similarity:	256/632 - (40%)	Gaps:	161/632 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 IGLKMVDFKVQ----------QRRYRTSEKTVVSTTYGPIKG--VKRKSIYGQSYFSFERIPFAK 64
            :|||.:..::.          |.:.:.|...:.:|..|.|.|  :..|.: .....||..|||||
  Rat     1 MGLKQIHARLTTAACGLLLLLQVQGQDSLSPIRTTHTGQILGSLIHMKGL-DVGVHSFLGIPFAK 64

  Fly    65 PPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQK------------HFVFEMTDGSEDCLYLNVYT 117
            ||:|.||:..|:.||.|:.||..||.....||.            .....:...||||||||:||
  Rat    65 PPIGPLRFAPPEAPEPWSGVRDGTSHPAMCLQDITAMNMQAFKLLKLTLPLIPMSEDCLYLNIYT 129

  Fly   118 KN-LYPTKPMPVMVWIYGGGFQFGEASRECYSPDYL-LREDVVVISINYRLGPLGTNDDTWKKKH 180
            .| .:....:||||||:||....|.||  .|....| ..|:|||::|.||||.|
  Rat   130 PNHAHEGSNLPVMVWIHGGALVIGMAS--LYDGSMLAAMENVVVVTIQYRLGVL----------- 181

  Fly   181 IFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMM 245
                   ||....|..  ..||.|..|||.||.||:.|.:.|||:...:||||:|||..||...:
  Rat   182 -------GFFSTGDQH--ARGNWGYLDQVAALHWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHV 237

  Fly   246 ITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKA 310
            ::..:.||||.||..||..|....::...:..||.........:.:::.:...|:.....||:..
  Rat   238 VSPMSRGLFHGAIMESGVALMSSLISVSSDVVYRTVANLSGCEQVDSKALVNCLRGKSEEEIMSI 302

  Fly   311 NGELCIDEEKKERI--GFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLY 373
            |        |..||  |          :.....:|:.|.|::.:|..:.||.|| ||:|
  Rat   303 N--------KAFRIISG----------IVDGIFLPRHPKELLASADFHPIPSII-GVNN------ 342

  Fly   374 SETKTNPKCLNELDDCRFVVPIEL-------NMDRE--SALCR----------EYGDQLRQCYYG 419
                         |:..:::|..:       .|||:  .|:.:          |:.|.|.:.|.|
  Rat   343 -------------DEYGWIIPSSMTTTDSKKKMDRQMVQAILQKRVAQMMWPPEFSDLLLEEYMG 394

  Fly   420 DKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYAR----SAPTYLYRFDFDSKHFN-----HL 475
            |.........::.:|:  |.|.|     |:..||.|.    :||.|.|.|......|.     |:
  Rat   395 DSEDPQFLQVQFKEMM--EDFTF-----VIPALQVAHFQRSNAPVYFYEFQHRPSFFKDSKPPHV 452

  Fly   476 RILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCI-ERLVGLWTHFAACGNPN------- 532
            :          ..|||::.::|.:.......:.|.|.:.: .|::..|.:||..||||
  Rat   453 K----------ADHGDEILFIFRSFWGGTQVDLTEEEELLSRRMMKYWANFARQGNPNSEGLPYW 507

  Fly   533 --FDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDVPDLKKLMVW 577
              ||.:::.|.....||           :...||.      |:|..|
  Rat   508 PVFDHDEQYLQLDTQPA-----------VGRALKA------KRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	163/577 (28%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	48/123 (39%)
Ces2h	NP_001037723.1	COesterase	30..537	CDD:278561	167/601 (28%)
Ces2h	NP_001037723.1	Aes	<127..>230	CDD:223730	49/124 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336463
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740