DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and ACHE

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001354847.1	Gene:	ACHE / 43	HGNCID:	108	Length:	681	Species:	Homo sapiens

Alignment Length:	577	Identity:	169/577 - (29%)
Similarity:	270/577 - (46%)	Gaps:	94/577 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RTSEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |...:.:|:...|.::|::.|: .|....:|..||||:||:|..|:..|:|.:.|:.|...|:.
Human   101 REDAELLVTVRGGRLRGIRLKT-PGGPVSAFLGIPFAEPPMGPRRFLPPEPKQPWSGVVDATTF- 163

  Fly    92 PKPLQKHFV------FEMTDG-------SEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEAS 143
             :.:...:|      ||.|:.       |||||||||:|....||.|.||:||||||||..|.:|
Human   164 -QSVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPTSPTPVLVWIYGGGFYSGASS 227

  Fly   144 RECYSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKD 207
            .:.|...:|:: |..|::|:|||:|..|.            ::|||       ..:.|||.||.|
Human   228 LDVYDGRFLVQAERTVLVSMNYRVGAFGF------------LALPG-------SREAPGNVGLLD 273

  Fly   208 QVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTP 272
            |.|||:||:.|.:.||||..::|:||:|||:|||...:::..:.||||:|:..||....||| |.
Human   274 QRLALQWVQENVAAFGGDPTSVTLFGESAGAASVGMHLLSPPSRGLFHRAVLQSGAPNGPWA-TV 337

  Fly   273 QRNWPYRLAVQ--------AGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFG 329
            ......|.|.|        .|..|.|:| ::...|:......::.....: :.:|...|  |||.
Human   338 GMGEARRRATQLAHLVGCPPGGTGGNDT-ELVACLRTRPAQVLVNHEWHV-LPQESVFR--FSFV 398

  Fly   330 PVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEG--LLLYSE---TKTNPKCLNELDDC 389
            ||::....|     ..|..::.....:.:.:::|.|.:||  .|:|..   :|.|...::..:
Human   399 PVVDGDFLS-----DTPEALINAGDFHGLQVLVGVVKDEGSYFLVYGAPGFSKDNESLISRAE-- 456

  Fly   390 RFVVPIELNMDRESALCRE-----YGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVL 449
             |:..:.:.:.:.|.|..|     |.|.|.     .:.|:  .|.|.|..|..::........:.
Human   457 -FLAGVRVGVPQVSDLAAEAVVLHYTDWLH-----PEDPA--RLREALSDVVGDHNVVCPVAQLA 513

  Fly   450 SRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKC 514
            .||. |:.|..|.|.|:       |...........|..||.::.::|...|... :|:|.|.|.
Human   514 GRLA-AQGARVYAYVFE-------HRASTLSWPLWMGVPHGYEIEFIFGIPLDPS-RNYTAEEKI 569

  Fly   515 I-ERLVGLWTHFAACGNPN--FDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDV 568
            . :||:..|.:||..|:||  .||:... |.|....|.:       .:|.:|:.::|
Human   570 FAQRLMRYWANFARTGDPNEPRDPKAPQ-WPPYTAGAQQ-------YVSLDLRPLEV 618

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	165/556 (30%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	51/122 (42%)
ACHE	NP_001354847.1	COesterase	104..630	CDD:395084	168/574 (29%)
ACHE	NP_001354847.1	AChE_tetra	645..678	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142774
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840