DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and CG4757

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001262469.1	Gene:	CG4757 / 41330	FlyBaseID:	FBgn0027584	Length:	550	Species:	Drosophila melanogaster

Alignment Length:	613	Identity:	170/613 - (27%)
Similarity:	254/613 - (41%)	Gaps:	156/613 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWT-EVRSCTSQG---PKP 94
            |.|..|.::|....|..|.::.:|..|.:|:||:|:||:..|||.:.|: ::...:..|   |:|
  Fly    23 VDTELGRVRGANLTSRLGVNFHAFRGIRYAEPPLGDLRFVNPQPVKPWSPKIFDASEDGPMCPQP 87

  Fly    95 LQKHFVFEMTDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQ-FGEASRECYSPDYLLREDVV 158
            ..     .|||.|||||.||||||:|...:  ||:|:::.|||. |...|:....|::.:..|.|
  Fly    88 WD-----NMTDVSEDCLRLNVYTKDLKGRR--PVIVFLHPGGFYVFSGQSKYLAGPEHFMDRDCV 145

  Fly   159 VISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFG 223
            ::|:|||||.|                  |||.....|  .|||||||||||||||::.:..|||
  Fly   146 LVSLNYRLGSL------------------GFLATGSKE--APGNAGLKDQVLALRWIQQHIQRFG 190

  Fly   224 GDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLAV-QAGY- 286
            ||..::|:.|.||||.||...|::..:.||||:.||||.   :|:.....::...:||. |||.
  Fly   191 GDPDSVTLLGYSAGSISVALHMLSPMSRGLFHRGICMSA---APYGPVKYKDNDLQLAKRQAGLL 252

  Fly   287 -AGENNTRDVWEFLKNAKGSEIIKA-NGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPK----- 344
             ..:.:..::.|.::.....:.:.. ||.            |.||  ..|.:....||.|
  Fly   253 KCPQESIGEMVECMRRKPYLDYVSTYNGM------------FEFG--WNPVLNWRIVVEKDFGQE 303

  Fly   345 -----KPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELD-DCRFVVPIELNMDRES 403
                 .|.:..|....:.:.||.|....|.|........|...:|..: |......|.|.:::.|
  Fly   304 RYLIESPFKTARRGDFHKVALITGITEFEFLSGAFFDLRNESIVNRYNRDWEHYASIALLLEQNS 368

  Fly   404 ALCREYGDQLRQCYYGDKTPSLD-------------------TLHEYLQMVS-HEYFWFPIYRTV 448
            ...|......|:.|..:....|:                   :.|.:||::| |.    |||
  Fly   369 TQSRAASRVFREKYMPESLDKLEYPKSLKGMGELLSDALIGVSFHRFLQLMSPHT----PIY--- 426

  Fly   449 LSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFY-NSLARKLKNHTREY 512
                       |||:|:   ...:..|:... .::..|..|.|:|.|||: ..|...||....|.
  Fly   427 -----------TYLFRY---KGRYTFLKNPD-NQQTIGPVHHDELIYLFHVGLLIPLLKREDPEN 476

  Fly   513 KCIERLVGLWTHFAACGNPNFDPEQEDLWQPVDPAAVEKHQLKCLNISDE-LKVIDVP------- 569
            ..||.|..:|..||..|:|:                         |.:|| ||.::.|
  Fly   477 FMIELLTRMWIEFAQKGDPH-------------------------NKNDEYLKGLNWPLYNAQDK 516

  Fly   570 ----------------DLKKLMVWESFF 581
                            .|.:..:||..|
  Fly   517 GYLEIGNNLTAKSGGFFLNRYQIWEDLF 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	160/561 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	50/122 (41%)
CG4757	NP_001262469.1	COesterase	15..540	CDD:278561	167/607 (28%)
CG4757	NP_001262469.1	Aes	40..>204	CDD:223730	76/190 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467416
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.790