DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and alpha-Est5

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001246965.1	Gene:	alpha-Est5 / 40905	FlyBaseID:	FBgn0261393	Length:	543	Species:	Drosophila melanogaster

Alignment Length:	558	Identity:	261/558 - (46%)
Similarity:	351/558 - (62%)	Gaps:	41/558 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 GPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQKHFVFEM 103
            |.||||||.|:|...|||||:|||||||:||||::||.|.:.|:.|..||....||.|:..:...
  Fly    18 GQIKGVKRLSLYDDPYFSFEKIPFAKPPLGELRFRAPVPADPWSGVLDCTHYAEKPTQRGLLTRE 82

  Fly   104 TDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEASRECYSPDYLLREDVVVISINYRLGP 168
            .:|.|||||||||:|.|...||:||||:||||.|..|||:||.|.|||.:.:|||::::|||:..
  Fly    83 IEGGEDCLYLNVYSKQLKSEKPLPVMVYIYGGAFTVGEATRELYGPDYFMTKDVVLVTLNYRVDC 147

  Fly   169 LGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFG 233
            |                  |||.|.||.|.||||||||||||||:|||...|.|.||.:|||:||
  Fly   148 L------------------GFLSLKDPSLKVPGNAGLKDQVLALKWVKQYISNFNGDDSNITVFG 194

  Fly   234 DSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLAVQAGYAGENNTRDVWEF 298
            :|||..|.|:||.||||.|||||||.|||...:.||..|..::.:|||.|.|:.|||:...|.|:
  Fly   195 ESAGGCSTHFMMCTEQTRGLFHKAIPMSGTVHNYWANNPAEDFAFRLAQQNGFTGENDDAKVLEY 259

  Fly   299 LKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIG 363
            |:.....:::  |..|...|.::..:.|:|||.:|.||...|||||.|:||.|.|||||.|:::|
  Fly   260 LQGVPARDLV--NHNLLTPEHRRNGLLFAFGPTVEAYVGEDCVVPKPPVEMARDAWSNNFPVMLG 322

  Fly   364 GVSNEGLLLYSETKTNPKCLNEL-DDCRFVVPIE---LNMDRESALCREYGDQLRQCYYGDKTPS 424
            |.|.|||.:|.....|.|.|:.| .|...:||::   ::.::|:.   ||..:|.:.|:|...||
  Fly   323 GTSFEGLFMYPAVSANLKALDSLSQDPTRLVPVDVRTVSSEKENL---EYSQRLMKAYFGYSPPS 384

  Fly   425 LDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVR-GTC 488
            .:.|...|...|::.||....||..:||.||: ||||.|||||||.:||..|...||.|:: |..
  Fly   385 SELLLNMLDFYSYKIFWHGFNRTFNARLTYAK-APTYYYRFDFDSPNFNFYRAKFCGDKIKTGVA 448

  Fly   489 HGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAACGNPNFDPEQEDL-WQPV---DPAAV 549
            |.|||||||.|:.:.||...:.||:.|||::|:||.|||..|||. ||...| |:|.   ||..|
  Fly   449 HADDLSYLFRNAGSWKLDKTSAEYRTIERMIGIWTAFAATSNPNC-PEIGHLEWKPSTKNDPKRV 512

  Fly   550 EKHQLKCLNISDELKVIDVPDLKKLMVWESFFRRDELL 587
                   :|||.::.:||:|:.:||.:|::.::.::|:
  Fly   513 -------INISSDVTIIDLPEYEKLQIWDNLYKPNQLI 543

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	251/524 (48%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	65/121 (54%)
alpha-Est5	NP_001246965.1	COesterase	7..510	CDD:278561	249/516 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467367
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26273
OrthoDB	1	1.010	-	-		D18817at7147
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	11	10.910