DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est9 and Est-Q

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_649321.1	Gene:	Est-Q / 40381	FlyBaseID:	FBgn0037090	Length:	559	Species:	Drosophila melanogaster

Alignment Length:	512	Identity:	138/512 - (26%)
Similarity:	236/512 - (46%)	Gaps:	89/512 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPK-PLQKHFVFEMTDGS-EDCLYLN 114
            :::..|..||||:||:.|||::.|.....||...:..:.|.: |:..:...:|:|.. ||||.|:
  Fly    65 RAFMQFRGIPFAEPPIEELRFRPPVARSPWTGTLNALNFGQRCPVITNLDSQMSDAELEDCLTLS 129

  Fly   115 VYTKNLYPTKPMPVMVWIYGGGFQFGEASRECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKK 179
            ||||||  :...|||.:||||||..|  |.|.:.|:|||.:|||::...||:|.||     |
  Fly   130 VYTKNL--SASQPVMFYIYGGGFYNG--SSEDHPPNYLLEKDVVLVVPQYRVGALG-----W--- 182

  Fly   180 HIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYM 244
                        |.....::||||.:.|.::||.||:.:.|.||||...:||||.|||:.....:
  Fly   183 ------------LSTYTEELPGNAPIADILMALDWVQMHISSFGGDPQKVTIFGQSAGAGVASSL 235

  Fly   245 MITEQT-HGLFHKAICMSGNTLSPWAVTPQ-RNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEI 307
            :::.:| ..:|.:||..||:..:.||:... :....|:.:|.|.:|......:.:.::.||..:|
  Fly   236 LLSPKTGDNMFKRAIVQSGSIFASWAINKDPKAQSRRICIQLGCSGCEQHDQLVKCIQKAKVIDI 300

  Fly   308 IKANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLL 372
            :||..            ..||.|::...   |.::|::|.|::: ::...||::.|...::|..:
  Fly   301 LKATA------------SESFSPIVGDL---HGILPQQPSELVK-SYRRQIPILTGFTQHDGSFV 349

  Fly   373 ----YSETKTNPKCLNELDDCRFVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDT------ 427
                |.........::.|...:|...|...::..|.|.....::|.     .|..:|::
  Fly   350 LASYYDALAAKVANVSSLSVRQFSQGINDLVNDTSGLTDNILNRLL-----FKPQALNSHDHSAA 409

  Fly   428 LHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFDSKH-------------FNHLRILS 479
            :..|..:.::.:...|:...........||.|.|:|.|:::..:             ||
  Fly   410 VSSYFDLTTNIFMKSPVITLATKMYTQQRSTPVYVYSFEYEGTYTRFGYEFGNSHYPFN------ 468

  Fly   480 CGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAACGNP-NFDP 535
                 .|..|.:|..|||   ....|:.  ::.:..:::|.:||.||..|.| |..|
  Fly   469 -----GGVHHSNDNIYLF---ATHPLEG--QDTQMSQKMVDVWTSFAIEGVPRNLSP 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	138/512 (27%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	51/121 (42%)
Est-Q	NP_649321.1	COesterase	39..544	CDD:278561	138/512 (27%)
Est-Q	NP_649321.1	Aes	<137..>240	CDD:223730	47/124 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.960