DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Jhe

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001163166.1	Gene:	Jhe / 36780	FlyBaseID:	FBgn0010052	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	573	Identity:	166/573 - (28%)
Similarity:	266/573 - (46%)	Gaps:	88/573 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 TVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQ-PPEVWTEVRSCTSQGPKP- 94
            ||...:.|.:||...:....:.:.:|..||:|.||:|:||:..|: .|::   :....:..||.
  Fly    33 TVCPPSVGCLKGTNLQGYQSERFEAFMGIPYALPPIGDLRFSNPKVMPKL---LGMYDASAPKMD 94

  Fly    95 -LQKHFVF--EMTDGSEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEASRECYSPDYLLRE- 155
             :||:::.  .:..|.|||||||||...:..: .:||||:|:||||..|.|......|:|.:..
  Fly    95 CIQKNYLLPTPVVYGDEDCLYLNVYRPEIRKS-ALPVMVYIHGGGFFGGSAGPGVTGPEYFMDSG 158

  Fly   156 DVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCS 220
            :|:::::.|||||.                  |||...|..:.  ||.|||||.||||||:.|..
  Fly   159 EVILVTMAYRLGPF------------------GFLSTQDAVMS--GNFGLKDQNLALRWVQRNIR 203

  Fly   221 RFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLAVQAG 285
            .||||...:||||.|||..:.|..:::.::|||||:.|.|||....|:|:..|.....||.  |.
  Fly   204 FFGGDPQRVTIFGQSAGGVAAHMHLLSPRSHGLFHRVISMSGTANVPFAIAEQPLEQARLL--AE 266

  Fly   286 YAGENNTRD-----VWEFLKNAKGSEIIKANGEL---CIDEEKKERIGFSFGPVIEPYVTSHCVV 342
            :|...:.|:     :.:.|:....::::.|...|   .:|...      :|.||:|..:.....:
  Fly   267 FADVPDARNLSTVKLTKALRRINATKLLNAGDGLKYWDVDHMT------NFRPVVEEGLEVDAFL 325

  Fly   343 PKKPIEMMRTAWSNNIPLIIGGVSNEGL-----LLYSETKTNPKCLNELDDCRF--------VVP 394
            ...|::|:......:|||::|.|..||.     :|.:||      |.:..:.||        ..|
  Fly   326 NAHPMDMLAQGMPTSIPLLLGTVPGEGAVRVVNILGNET------LRQSFNLRFDELLQELLEFP 384

  Fly   395 IELNMDRESALCREYGDQLRQCYY-GDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSA 458
            ...:.||...:.    |.|.:.|: |....:..|:..::.::|...|..|:|.|:...:.:..:
  Fly   385 ASFSQDRREKMM----DLLVEVYFQGQHEVNELTVQGFMNLISDRGFKQPLYNTIHKNVCHTPN- 444

  Fly   459 PTYLYRFDFD-----SKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLA-RKLKNHTREYKCIER 517
            |.|||.|::.     :..:....:  .||  .|..|.|||.|||.:.|. ...:.::.|.|.|..
  Fly   445 PVYLYSFNYQGPLSYASAYTSANV--TGK--YGVVHCDDLLYLFRSPLLFPDFQRNSTEAKVIHS 505

  Fly   518 LVGLWTHFAACGNPNFDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDVPD 570
            .|..:.|||..|.|.   ..|.|    .|.::|..|.:...|.|..:..:.||
  Fly   506 FVDYFVHFAKFGKPR---NSESL----TPCSIEVLQSRPDGICDYHEFANAPD 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	161/555 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	48/122 (39%)
Jhe	NP_001163166.1	COesterase	40..527	CDD:278561	157/540 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440417
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	7	6.790