DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and CG9289

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_609245.1	Gene:	CG9289 / 34195	FlyBaseID:	FBgn0032058	Length:	674	Species:	Drosophila melanogaster

Alignment Length:	571	Identity:	156/571 - (27%)
Similarity:	241/571 - (42%)	Gaps:	121/571 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 KVQ------QRRYRTSEKTVVSTTYGPIKGVKRKSI----YGQSYFSFERIPFAKPPVGELRYKA 74
            |||      |:.....|..|.:||...:..::.:::    .||....|..||:.|..    |::.
  Fly    56 KVQKQKPNKQQGQNGQEPKVFTTTVPDLGRLRGRTLTTDWTGQKIMQFLDIPYGKAE----RFRP 116

  Fly    75 PQPPEVWTEV-------RSCTSQGPKPLQKHFVFEM--TDG--SEDCLYLNVYTKNLYPTKPMPV 128
            .:|...|..|       ..|.|     :|...||..  .||  .||||.|:|.||.: ..|.:||
  Fly   117 AEPAPSWKGVLPAHRPHAGCPS-----IQDLIVFAKLEEDGFDVEDCLRLSVNTKAM-EGKSLPV 175

  Fly   129 MVWIYGGGFQFGEASRECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFL-CL 192
            ||:|:|..|..|::...  :|.|||..|||::|:.|||||.                  ||| .|
  Fly   176 MVYIHGDFFYDGDSVEA--APGYLLEHDVVLVSVRYRLGPF------------------GFLSTL 220

  Fly   193 DDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQT-HGLFHK 256
            .|   ::||||.:.|.:|||:||:.:.:.||||...:|:||...|:|.|:.:.::... .||||:
  Fly   221 TD---EMPGNAAVTDIILALKWVQQHIASFGGDPQRVTLFGQVGGAALVNVLTLSPAVPAGLFHR 282

  Fly   257 AICMSGNTLSPWAVTPQRNWPYRLAVQAG-YAGENNTRDVWEFLK--NAKGSEIIKA----NGEL 314
            .|..||..|||..:|   :.|.......| .||...:..|.:..|  |...:.::.|    :|
  Fly   283 VIYQSGTALSPAFIT---DAPLGATKAIGRIAGCKQSTKVDQLNKCLNRLNATMLLAAFSVHG-- 342

  Fly   315 CIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTN 379
               |.:....|.::|.|.........::|:.|..::........|.:.|.|.:.|..:..:...:
  Fly   343 ---ENQPSLSGGAYGGVQLVIGGPSGILPEHPGRLLAAEKFQAYPTMGGSVKHGGTFMLRDIFAD 404

  Fly   380 PKCLNE--LDDC----RFVVPI--ELNMDRESALCREYGDQ-------LRQCYYGDKTPSLDTLH 429
              ..||  |||.    :::..|  :.|....|...:|:.|:       ::...:...||.|..|.
  Fly   405 --IFNETILDDTMTGRQYIDTIIEQANGADPSGSWKEFSDEEIFTQNDVKNGTFKRLTPGLIDLC 467

  Fly   430 EYLQMVSHEYFWFPIYRTVLSRLQ-YARSAP--TYLYRFDFDSKHFNHLRILSCGKKV------- 484
            ..:.:.:          .||..|| .|:..|  ||||.||::.:...:    :.|:..
  Fly   468 STISLKN----------PVLLVLQANAKKLPNSTYLYSFDYEGEQNRY----ATGEDEANFVPFD 518

  Fly   485 RGTCHGDDLSYLF----YNSLARKLKNHTREYKCIERLVGLWTHFAACGNP 531
            .|....||..|||    :.:|     |..|:.|...|:|.|||.||..|.|
  Fly   519 MGVSLTDDNLYLFPWPRFLAL-----NSNRDLKVARRMVALWTSFATTGVP 564

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	151/552 (27%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	47/122 (39%)
CG9289	NP_609245.1	COesterase	83..600	CDD:278561	148/544 (27%)
CG9289	NP_609245.1	Aes	<171..351	CDD:223730	68/210 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467450
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.840