DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and CG9287

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_609244.1	Gene:	CG9287 / 34194	FlyBaseID:	FBgn0032057	Length:	625	Species:	Drosophila melanogaster

Alignment Length:	585	Identity:	157/585 - (26%)
Similarity:	242/585 - (41%)	Gaps:	123/585 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 MVDFKVQQRRYRTSEKTVVS-TTYGPIKG-------VKRKSIYGQSYFSFERIPFAKPPVGELRY 72
            :|:.:|:.|:|...:.|:|. .|.|.|:|       .||:.:      .|..:.:|:||.|..|:
  Fly    18 VVESRVRGRQYDEEKDTIVELPTLGSIQGKILETAWTKREVL------QFVDVRYAEPPTGLHRF 76

  Fly    73 KAPQPPEVWTEVRSCTSQG---PKPLQKHFVFEMTD--GSEDCLYLNVYTKNLYPTKPMPVMVWI 132
            |||:|.|.|.:|...|::.   |..:....:..:.|  ..||||.:.:.|.|:  |..:||:|:|
  Fly    77 KAPRPIEPWEDVMDATAEKIGCPSVVSMDSLRRLDDVLDVEDCLTMTITTPNV--TSRLPVLVYI 139

  Fly   133 YGGGFQFGEASRECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPEL 197
            :|.....|..|..  .|||||.:|||:::..|||||.                  |||.....|
  Fly   140 HGEYLYEGSNSEA--PPDYLLEKDVVLVTPQYRLGPF------------------GFLSTKTDE- 183

  Fly   198 DVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQT-HGLFHKAICMS 261
             :|||||..|..|||::||.....||||.:.:|:.|...|:|..|.:.::... .||||:.|..|
  Fly   184 -IPGNAGFLDIFLALQFVKHFIKYFGGDPSRVTVAGQVGGAAIAHLLTLSPVVQRGLFHQVIYHS 247

  Fly   262 GNTLSP-WAVTPQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIG 325
            |:.:.| :.....|.....:|.:|. ......||:...|......|::.|..|..::   |..:|
  Fly   248 GSAIMPIFLEEDPRKHAQEIAKKAD-CKMVTVRDLNTCLMELTALELLTAFMEHALE---KSDLG 308

  Fly   326 FSF---------GPVIEPYVTSHCVVPKKPIE-MMRTAWSNNIPLIIGGVSNEGLLLYSETKTNP 380
            ...         ||        ..|:||.|.: |:.|.:|  .|.:.|...|.|          .
  Fly   309 IGHTGGIQFTIGGP--------SGVLPKHPYDLMLETNFS--YPAMGGCPKNAG----------S 353

  Fly   381 KCLNELDDCRFVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPI- 444
            :.|||:.|..|...|.   |.|..........:||....|||..|.:      .|:|::|...:
  Fly   354 RVLNEIVDNDFEGKIP---DDEYNTYNYIDHVIRQTVGTDKTMLLTS------FVTHDFFNRNLM 409

  Fly   445 ----YRTVLSRL------------------QYARSAP--TYLYRFDFDSKHFNHLRILSCGKKVR 485
                :.|::.||                  ...:..|  |:||.||: :..||..:.:.....::
  Fly   410 ENGTFDTLIPRLIDVAGTLNHKLPVLLALNMNNKHNPDNTFLYSFDY-AGEFNRYKEMDEETNLQ 473

  Fly   486 -----GTCHGDDLSYLF-YNSLARKLKNHTREYKCIERLVGLWTHFAACGNPNFDPEQEDLWQPV 544
                 |....|:..||| |.....:|..  .:.....|:|.|||:|...||| ....:...|.|:
  Fly   474 SPFKAGVSLTDEALYLFPYPEHVTRLSR--PDQSMAHRMVELWTNFVISGNP-LGSARVGYWPPM 535

Fly 545 544
Fly 536 535

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	152/568 (27%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	44/121 (36%)
CG9287	NP_609244.1	COesterase	31..558	CDD:278561	153/572 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467464
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	5	4.890