DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Glt

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001245946.1	Gene:	Glt / 34193	FlyBaseID:	FBgn0001114	Length:	1026	Species:	Drosophila melanogaster

Alignment Length:	586	Identity:	155/586 - (26%)
Similarity:	247/586 - (42%)	Gaps:	116/586 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LKMVDFKVQQRRYRTSEKTVVSTTYGPIKGVK-RKSIYGQSYFSFERIPFAKPPVGELRYKAPQP 77
            ||.|.::.:.|..:..|..|.:...|.|.|:. .|:|..:...:|..|.:.....|..|::|.||
  Fly    43 LKPVPWQSETRYAQPQEAVVQAPEVGQILGISGHKTIANRPVNAFLGIRYGTVGGGLARFQAAQP 107

  Fly    78 PEVWTEVRSCTSQGPKPLQKHFVFEMTD----------GSEDCLYLNVYTKNLYPTKPMPVMVWI 132
            ......| :.|.|.|...|    |...|          ..:|||.|::|...  ....:||:|::
  Fly   108 IGYQGRV-NATVQSPNCAQ----FPELDRLRLSESRGENVDDCLTLDIYAPE--GANQLPVLVFV 165

  Fly   133 YGGGFQFGEASRECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFL-CLDDPE 196
            : |...|...|.|. .|||:|.:||:::||||||.|.                  ||| .|.|
  Fly   166 H-GEMLFDGGSEEA-QPDYVLEKDVLLVSINYRLAPF------------------GFLSALTD-- 208

  Fly   197 LDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMS 261
             ::|||..|.|..|||.|::.|...|||::..:|:.|.:.|:...|.:.::.:...||.:.|..|
  Fly   209 -ELPGNVALSDLQLALEWLQRNVVHFGGNAGQVTLVGQAGGATLAHALSLSGRAGNLFQQLILQS 272

  Fly   262 GNTLSPWAVTPQRNWPY-------RLA------VQAGYAGENNTRDVWEFLKNAKGSEIIKANGE 313
            |..|:|:.:.   |.|.       |||      :.....|   .:.:::.|.....|:::.|..:
  Fly   273 GTALNPYLID---NQPLDTLSTFARLARCPPPSINPSAQG---LKPLYDCLARLPTSQLVAAFEQ 331

  Fly   314 LCIDEEKKERIGFS----FGPVI-EP--YVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLL 371
            |.:   :.|.:|.:    |..|: :|  ::.||      |.. :.|..|..:|:|||...:....
  Fly   332 LLL---QNEHLGLTQLGGFKLVVGDPLGFLPSH------PAS-LATNSSLALPMIIGATKDASAF 386

  Fly   372 LYSE-----TKTNPKCLNELDD--CRFVVPIELNMDRESALCREYGDQLRQCY--YGDKTPSLDT 427
            :.|.     .:...:.:::..|  .|...|     ..|..|.:::.  ||:.:  ..::|.||.|
  Fly   387 IVSRIYDQLARLQSRNVSDYIDVVLRHTAP-----PSEHRLWKQWA--LREIFTPIQEQTASLQT 444

  Fly   428 LHEYLQMVSHEYFWFPIYR--TVLSRLQYARSAPTYLYRFDFDSKH--FNHL-RILSCGKKVRGT 487
            :...|..:|:    :.:||  .:.|..|..||.|.|||.||:..:|  |.|| ..|..|.   ..
  Fly   445 VAPGLLELSN----YILYRAPVINSISQSYRSVPAYLYTFDYRGEHHRFGHLSNPLPFGV---DA 502

  Fly   488 CHGDDLSYLF-YNSLARKLKNHTREYKCIERLVGLWTHFAACGNPNFDPEQEDLWQPVDPAAVEK 551
            ...||..||| |...|.:|....|...  ..||.:|.:||..|.||   ....:|    |.|..:
  Fly   503 SLSDDSVYLFPYPPEASRLNPLDRSLS--RALVTMWVNFATTGVPN---PSSGVW----PQATSE 558

  Fly   552 H 552
            :
  Fly   559 Y 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	150/567 (26%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	41/122 (34%)
Glt	NP_001245946.1	COesterase	55..579	CDD:278561	151/574 (26%)
		Aes	<146..345	CDD:223730	64/232 (28%)
		RILP-like	<677..>717	CDD:304877
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467436
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR43142
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940