DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est9 and Ces4a

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001099646.1	Gene:	Ces4a / 291955	RGDID:	1307418	Length:	563	Species:	Rattus norvegicus

Alignment Length:	568	Identity:	162/568 - (28%)
Similarity:	255/568 - (44%)	Gaps:	120/568 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPK 93
            :::.::.|.:|.::| |:..:.......|..:||::||||..|:..|:||..|..:|..|:..|.
  Rat    31 TKEPLLITKHGILQG-KQVHVGDTPIRVFLGVPFSQPPVGTRRFAPPEPPLPWNGIRDATTYPPS 94

  Fly    94 PLQKHF------------VFEMTDGSEDCLYLNVYTKNLYPTKP-MPVMVWIYGGGFQFGEASRE 145
            .||:.:            .:|....||||||||||...|.|..| :|||||..||.|..|.||
  Rat    95 CLQESWGQITSMYLNTRKQYEWLHFSEDCLYLNVYAPVLAPGDPLLPVMVWFPGGAFLVGSAS-- 157

  Fly   146 CYSPDYL-LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQV 209
            .|....| .|..||::.:.||||.||          .|:..          .....||.||.||:
  Rat   158 TYEGSELAARGKVVLVFLQYRLGILG----------FFSTG----------NSHARGNWGLLDQI 202

  Fly   210 LALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVT--P 272
            .|||||:.|...||||..::|:||.|||:.||..::::....||||:||..||..:....:|  |
  Rat   203 AALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLLMSPLAQGLFHQAISQSGTAVLKTFITHDP 267

  Fly   273 QRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEII---------KANGELCIDEEKKERIGFSF 328
            .:: ..::|..|| ...|:|:.:.:.||.....:::         :||..    ::.|:.:.| .
  Rat   268 LKS-AKKIAHLAG-CDHNSTKIMVKCLKALPAEKVMLVSKKMTFFRANSH----KDPKDIVWF-L 325

  Fly   329 GPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNE---GLLLYSETKTNPKCLNE----- 385
            .||::     ..|.|:.|:.::.......:|.::|..|.|   .|....:.:.|.:.:|:
  Rat   326 SPVVD-----GLVFPEDPVVLLTRGQVKPVPYLLGVNSAEFEWSLPFLMKLQLNQRIMNKNYITK 385

  Fly   386 -LDDCRFVVPIELNMDRES--ALCREY-GDQLRQCYYGDKTPSLDTLHEY-------LQMVSHEY 439
             |..|    .|.||:..|.  .:.||| .|.:..             |::       :.:|....
  Rat   386 LLWSC----SILLNITEEQIPLVAREYLSDAISH-------------HDWKMFRNHLIDLVGDAT 433

  Fly   440 FWFPIYRTVLSRLQYARSA--PTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLA 502
            |   :|.| |...:|.|.|  |.|||.|    ||  |...:....:..|..|||:|||||.:..:
  Rat   434 F---VYAT-LQAARYHRDAGSPVYLYEF----KH--HAPGIIVKPRSDGADHGDELSYLFGSPFS 488

  Fly   503 R-KLKNHTREYKCIERLVGLWTHFAACGNPN---------FDPEQEDL 540
            : ..:...:|:..  :::..|.:||..|:||         ||.|::.|
  Rat   489 KGSSRGEEKEFSL--QMMKYWANFAHTGDPNDRELPYWPRFDKEEKYL 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	162/564 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	48/123 (39%)
Ces4a	NP_001099646.1	COesterase	33..554	CDD:395084	162/566 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336428
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740