Protein Alignment alpha-Est9 and CES4A

DIOPT Version :9

• Sequence 1: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 590
• Identity: 163/590 - (27%)
• Similarity: 254/590 - (43%)
• Gaps: 146/590 - (24%)

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCT----- 88
            :::..|.|.||.::| |:..:.......|..:||::||:|.||:..|:|||.|..:|..|
Human    47 TKRPQVVTKYGTLQG-KQMHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIRDATTYPPG 110

  Fly    89 -----SQG----------------------PKPLQ---------------KHFV-----FEMTDG 106
                 |.|                      |:||.               ..:|     ::....
Human   111 WSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASMYVSTRERYKWLRF 175

  Fly   107 SEDCLYLNVYTKNLYPTKP-MPVMVWIYGGGFQFGEASRECYSPDYLLREDVVVISINYRLGPLG 170
            ||||||||||.....|..| :|||||..||.|..|.|| .....|...||.||::.:.:|||..|
Human   176 SEDCLYLNVYAPARAPGDPQLPVMVWFPGGAFIVGAAS-SYEGSDLAAREKVVLVFLQHRLGIFG 239

  Fly   171 TNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDS 235
            ..  .|:.:            .||..  ..||.||.||:.|||||:.|.:.||||..|:|:||.|
Human   240 FL--RWRGR------------TDDSH--ARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQS 288

  Fly   236 AGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLAVQAGY-AG--ENNTRDVWE 297
            ||:.|:..:|::....||||:||..||..|....:|..   |.::|.:..: ||  .|:|:.:..
Human   289 AGAMSISGLMMSPLASGLFHRAISQSGTALFRLFITSN---PLKVAKKVAHLAGCNHNSTQILVN 350

  Fly   298 FLKNAKGSEIIKANGELCI----DEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNI 358
            .|:...|:::::.:.::..    .:...|.|.:|..||::     ..|:|..|:.::.....:::
Human   351 CLRALSGTKVMRVSNKMRFLQLNFQRDPEEIIWSMSPVVD-----GVVIPDDPLVLLTQGKVSSV 410

  Fly   359 PLIIGGVSN---EGLLLY------------SETKTNPKCLNELDDCRFVVPIELNMDRESA--LC 406
            |.:: ||:|   ..||.|            .||.|  |.|       :.....||:.:|..  :.
Human   411 PYLL-GVNNLEFNWLLPYIMKFPLNRQAMRKETIT--KML-------WSTRTLLNITKEQVPLVV 465

  Fly   407 REYGDQLRQCYYGDKTPSLDTLHEY-------LQMVSHEYFWFPIYRTVLSRLQYARSA--PTYL 462
            .||.|.:.:             |::       :.:|....|   :|.| |....|.|.|  |.||
Human   466 EEYLDNVNE-------------HDWKMLRNRMMDIVQDATF---VYAT-LQTAHYHRDAGLPVYL 513

  Fly   463 YRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAA 527
            |.|:      :|.|.:....:..|..|||::.:||....|..| :..:|.....:::..|.:||.
Human   514 YEFE------HHARGIIVKPRTDGADHGDEMYFLFGGPFATGL-SMGKEKALSLQMMKYWANFAR 571

  Fly   528 CGNPN 532
            .||||
Human   572 TGNPN 576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	163/586 (28%)
		Aes	<115..>237	CDD:223730	48/122 (39%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	163/590 (28%)
		Aes	<184..>291	CDD:223730	49/123 (40%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142757
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790