DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and SPCC417.12

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_588289.2	Gene:	SPCC417.12 / 2539430	PomBaseID:	SPCC417.12	Length:	539	Species:	Schizosaccharomyces pombe

Alignment Length:	577	Identity:	128/577 - (22%)
Similarity:	211/577 - (36%)	Gaps:	164/577 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 FERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQ----GPKPLQKH---------FVFEMTDGSE 108
            |..|.:||||||:||::.|...|...:.....:|    .|:|...:         |.::     |
pombe    40 FTGIRYAKPPVGKLRWRRPVTLEDGYDYSGDYNQFKTICPQPFYNNRKNQVRNPDFKYD-----E 99

  Fly   109 DCLYLNVYT-KNLYPTKPMPVMVWIYGGGFQFGEA--SRECYSPDYLLRED-----VVVISINYR 165
            |||:||::. ....|.:..||:.:|:||..|.|..  .|:|...|  |:.|     .:::|..:|
pombe   100 DCLFLNIWVPAGEKPAEGWPVLYFIHGGWLQVGNPLHYRQCDPQD--LQADGSPAKFILVSPGHR 162

  Fly   166 LGPLGTNDDTWKKKHIFNISLPGFLC-----LDDPELDVPGNAGLKDQVLALRWVKANCSRFGGD 225
            |                  :|.|||.     .:||:   ..|.|..||.|.|.|...:...|||:
pombe   163 L------------------NLFGFLAGKELLEEDPK---SSNFGFWDQRLGLEWTYKHIESFGGN 206

  Fly   226 SANITIFGDSAGSASVHYMMITEQTH----GLFHKAICMS-GNTLSPWAVTPQRNWPYRLAVQAG 285
            ..||.:.|.||||.|..:.:|.|..|    .:..:|:.:| |.::.|.:|...:.....||.:.|
pombe   207 KENIAVGGISAGSYSALFQLIYETYHPEANQIIKRALLLSNGLSVQPKSVEESQIQFNELAQKFG 271

  Fly   286 YAGENNTRDVWEFLKNAKGSEIIK-------------ANGELCIDEEKKERIGFSFGPVIEPYVT 337
            ...|.::.:..|.|:.....::..             .:|:.......|:....:||..|.
pombe   272 IPLELSSAEKLEKLRAIPFQDLADNILNLRLHTFRAVTDGDFVNPNTFKDIYDGTFGKRIR---- 332

  Fly   338 SHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSET---KTNPKCLNELDDCRFVVPIELNM 399
                             .:...||||.|:||. .:|:.|   |:.....|::::   ..|.::.
pombe   333 -----------------DSGRELIIGEVNNEH-SIYANTNPPKSKEDLFNQVNN---YYPEKVT- 375

  Fly   400 DRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQ-YARS------ 457
               .||...|          .|.|.::...|||..:.      .::.:::|.:| ||.:
pombe   376 ---KALLELY----------PKVPDMEDEKEYLAAIK------ALFGSIVSDMQVYASTRVLING 421

  Fly   458 --------APTYLYRFDFDSKHFNHLR----ILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTR 510
                    ...|.||..|..|.|:...    ::.         |..||...|||.:...|.....
pombe   422 LVKGGVPLEKIYRYRIAFRGKFFDKYEPPESLVP---------HAGDLGLWFYNVVDGILPEEIP 477

  Fly   511 EYKCIERLVGLWTHFAACGNPNFDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVID 567
            .||...:..|.|   .:.|.             .|....:..:.:.|:....:||:|
pombe   478 IYKAWLKSYGEW---MSTGK-------------TDWGTTKTEEYRLLDADGTIKVVD 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	124/563 (22%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	36/134 (27%)
SPCC417.12	NP_588289.2	PnbA	20..534	CDD:225181	128/577 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	99	1.000	Inparanoid score	I1664
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43142
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.050