DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Tg

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_112250.2	Gene:	Tg / 24826	RGDID:	3848	Length:	2768	Species:	Rattus norvegicus

Alignment Length:	577	Identity:	149/577 - (25%)
Similarity:	238/577 - (41%)	Gaps:	169/577 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKG----VKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEV------W-- 81
            |..:|...::|.::|    ||..:.:.|.| .|..:|:|.||:.|.|::|   |||      |
  Rat  2198 STPSVHIDSFGQLQGGSQVVKVGTAWKQVY-QFLGVPYAAPPLAENRFQA---PEVLNWTGSWDA 2258

  Fly    82 TEVR-SCTSQG---PKPLQKHFVFEMTDGSEDCLYLNVYT-KNLYPTKPMPVM----VWIYGGGF 137
            |::| ||...|   |.|.|.         |||||||||:. :||.....:.|.    |.:.|.|.
  Rat  2259 TKLRSSCWQPGTRTPTPPQI---------SEDCLYLNVFVPENLVSNASVLVFFHNTVEMEGSGG 2314

  Fly   138 QFG-EASRECYSPDYLLRE--DVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDV 199
            |.. :.|        :|..  :::|::.|||||             :|     |||.....|  |
  Rat  2315 QLNIDGS--------ILAAVGNLIVVTANYRLG-------------VF-----GFLSSGSDE--V 2351

  Fly   200 PGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGS--ASVHYMMITEQTH-GLFHKAICMS 261
            .||.||.|||.||.||:.:...||||...:|:..|..|:  ||:| ::||..|. .||.||:.|.
  Rat  2352 AGNWGLLDQVAALTWVQTHIGAFGGDPQRVTLAADRGGADVASIH-LLITRPTRLQLFRKALLMG 2415

  Fly   262 GNTLSPWA-VTPQR--NWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIK------ANGELCID 317
            |:.|||.| ::|.|  .....||.:.|             ..|:...|::.      ||   .::
  Rat  2416 GSALSPAAIISPDRAQQQAAALAKEVG-------------CPNSSVQEVVSCFRQKPAN---ILN 2464

  Fly   318 EEKKERIGFS-----FGPVIE-PYVTSHCVVP----KKPIEMMRTAWSNNIPLIIGGVSNEGLL- 371
            |.:.:.:..|     :|||:: .|:..   :|    |:|:.:       .:.|:|||..::||:
  Rat  2465 EAQTKLLAVSGPFHYWGPVVDGQYLRE---LPSRRLKRPLPV-------KVDLLIGGSQDDGLIN 2519

  Fly   372 --------LYSETKTNPKCLNELDDCRFVVPIELNMDRESALCREYGDQLRQCYYG--DKTPSLD 426
                    ..|:.:||.|       ..|...::.::..|.:..|.....:  .||.  ..|....
  Rat  2520 RAKAVKQFEESQGRTNSK-------TAFYQALQNSLGGEDSDARILAAAI--WYYSLEHSTDDYA 2575

  Fly   427 TLHEYLQMVSHEYFWF-PIYRTVLSRLQYARS-APTYLYRFDFDSKHFNHLRILSCGKKVRGTCH 489
            :....|:..:.:||.. ||..  ::.|...|: ...::|... :|.....|.:|:
  Rat  2576 SFSRALENATRDYFIICPIVN--MASLWARRTRGNVFMYHVP-ESYGHGSLELLA---------- 2627

  Fly   490 GDDLSYLF----------YNSLARKLKNHTREYKCIERLVGLWTHFAACGNPNFDPE 536
              |:.|.|          |.|:        .|.....:::..:::|...||||:..|
  Rat  2628 --DVQYAFGLPFYSAYQGYFSM--------EEQSLSLKVMQYFSNFIRSGNPNYPHE 2674

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	148/573 (26%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	39/129 (30%)
Tg	NP_112250.2	TY	34..93	CDD:238114
		TY	96..161	CDD:238114
		TY	164..249	CDD:294100
		TY	301..359	CDD:238114
		TY	<613..658	CDD:238114
		TY	661..724	CDD:238114
		TY	730..>776	CDD:294100
		TY	<893..922	CDD:238114
		TY	1005..1074	CDD:238114
		TY	1150..1211	CDD:238114
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1455..1468
		GCC2_GCC3	1464..1509	CDD:285001
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1469..1485
		Type II. /evidence=ECO:0000250\|UniProtKB:P01266	1486..1502
		TY	1519..1566	CDD:214561
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1602..1722
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1723..1891
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	1892..1994
		Type IIIB. /evidence=ECO:0000250\|UniProtKB:P01266	1995..2127
		Type IIIA. /evidence=ECO:0000250\|UniProtKB:P01266	2128..2185
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		149/577 (26%)
		COesterase	2198..2719	CDD:278561	149/577 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2731..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336497
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930