DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces2a

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	181/606 - (29%)
Similarity:	264/606 - (43%)	Gaps:	154/606 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKG----VK--RKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSC 87
            |...:.:|..|.::|    ||  :..|:     :|..|||||||||.||:..|:.||.|:.||..
  Rat    29 SASPIRNTHTGQVRGSFVHVKDTKSGIH-----TFLGIPFAKPPVGPLRFAPPEDPEPWSGVRDA 88

  Fly    88 TSQGPKPLQKHF-----VFEM------TDGSEDCLYLNVYT-------KNLYPTKPMPVMVWIYG 134
            |||....||...     :.||      |..||||||||:||       .||      ||||||:|
  Rat    89 TSQPAMCLQTDIMNLDGIKEMKLTVHPTPMSEDCLYLNIYTPAHAREGSNL------PVMVWIHG 147

  Fly   135 GGFQFGEASRECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDV 199
            ||...|.||....| .....|::|::||.||||.|                  ||....|.  :.
  Rat   148 GGLVLGSASMNDAS-TLAATEEIVIVSIQYRLGVL------------------GFFSTGDQ--NA 191

  Fly   200 PGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNT 264
            .||.|..|||.|||||:.|.:.|||:...:||||.|||..||...:::..:.||||.||..||..
  Rat   192 RGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHVVSPMSKGLFHGAIMQSGVA 256

  Fly   265 LSPWAVTPQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGEL-CIDEEKKERIGFSF 328
            |.|..::                  :.:..|::.:.|..|.|...:...: |:..:.|:.| .:.
  Rat   257 LLPDLIS------------------DKSEVVYKTVANLSGCEAPDSEALIRCLRAKSKQEI-LAI 302

  Fly   329 GPVIE--PYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRF 391
            ..|.:  |.|.....:||.|.|::.:...:.:|.|||                   :| .|:|.:
  Rat   303 NQVFKMIPGVVDGKFLPKHPQELLASGDFHPVPSIIG-------------------IN-TDECGW 347

  Fly   392 VVPIELNMD-------RES------------ALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSH 437
            .:|:.|.:|       ||:            .|..|..|.:.:.|.|| |.:.:||.|..:.:..
  Rat   348 GIPVFLGLDHIIKKITRETLPTVLKSTAAQMMLPPECIDLIMEEYMGD-TENPETLQEQFRHMLG 411

  Fly   438 EYFWFPIYRTVLSRLQYAR----SAPTYLYRFDFDSKHFNHLRILSCGKKVRGT----CHGDDLS 494
            ::.:      |:..||.|.    .||.|.|       .|.||.  |..|:||.:    .||||:.
  Rat   412 DFMF------VIPALQVAHFQRSQAPVYFY-------EFQHLP--SFIKQVRPSHVKADHGDDIL 461

  Fly   495 YLFYNSLARKLKNHTREYKCIE-RLVGLWTHFAACGNPNFDPEQEDL--WQPVDPAAVEKHQLKC 556
            ::|.:.|.....:.|.|.:.:: |::..|.:||..||||    .|||  |..:|      |..:.
  Rat   462 FVFGSYLWGMTFDLTEEEELLKRRVMKYWANFARTGNPN----GEDLPHWPVLD------HDEQY 516

  Fly   557 LNISDELKVIDVPDLKKLMVW 577
            |.::.:..|......::|..|
  Rat   517 LQLNTQPAVGRALKARRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	176/578 (30%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	49/128 (38%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	179/603 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336226
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840