DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces1a

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_001013786.2	Gene:	Ces1a / 244595	MGIID:	3648919	Length:	563	Species:	Mus musculus

Alignment Length:	605	Identity:	166/605 - (27%)
Similarity:	259/605 - (42%)	Gaps:	127/605 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYG--QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |...||.|..|.:.| |..|:.|  |....|..:||||||:|.||:..|||.|.|:.|::.||..
Mouse    21 SSPPVVDTLQGKVMG-KYISLEGSAQPVAVFLGVPFAKPPLGPLRFAPPQPAETWSSVKNTTSYP 84

  Fly    92 P---------KPLQKHFVFEM----TDGSEDCLYLNVYTKNLYPTKP-MPVMVWIYGGGFQFGEA 142
            |         ..|...|..::    .:.||||||||:|:.....:|. :|||||::|||...|.|
Mouse    85 PMCSQITGVGPVLSDVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLLSGGA 149

  Fly   143 SRECYSPDYL---LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAG 204
            |    :.|.|   ..|:||::.|.||||       .|           |||...|..  ..||.|
Mouse   150 S----TFDGLALSTHENVVIVVIQYRLG-------IW-----------GFLSTGDEH--SRGNWG 190

  Fly   205 LKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWA 269
            ..|||.||:||:.|.:.||||.:::|:||:|||..||..::::..|..||.:||..||..|:|..
Mouse   191 HLDQVAALQWVQNNIANFGGDPSSVTLFGESAGGESVSVLVLSPLTKNLFQRAISESGVALTPCL 255

  Fly   270 VTPQRNWPYRLAVQAGYAG---ENNTRDVWEFLKNAKGSEIIKANGEL---CIDEEKKERIGFSF 328
            .   |....|.|.|...|.   ...:.|:...|:.....|::....::   .:|.....|..:
Mouse   256 F---RETTRRAAEQVAIATGCVATTSADIVHCLREKTEEELLATTLKMKFFALDLLGDPRESY-- 315

  Fly   329 GPVIEPYVTS---HCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCR 390
                 |::|:   ..|:||.|.|::.....|.:|.|:|                   :|:.:...
Mouse   316 -----PFLTTVIDGVVLPKAPEEILAEKSFNTVPYIVG-------------------INKQEFGW 356

  Fly   391 FV-----VPI-ELNMDRESA------------LCREYGDQLRQCYYG-----DKTPSLDTLHEYL 432
            |:     .|: |..:|::||            :.:|......:.|.|     ||...|     :|
Mouse   357 FIPMMMGYPLSEGKLDQKSATSLLWKSYPLTNISKELTPVATEKYLGGSDCPDKKKDL-----FL 416

  Fly   433 QMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLF 497
            .|:....|..|  ..:::|......||||:|.|.:.....:.:|     .|.....|||:: |..
Mouse   417 DMMGDVLFAVP--SVIVARYHRDAGAPTYMYEFKYHPSFVSDMR-----PKTVIADHGDEV-YSV 473

  Fly   498 YNSLARKLKNHTREYKCIERLVGLWTHFAACGNPNFD-----PE--QEDLWQPVDPAAVEKHQLK 555
            :.:...|......|......::..|.:||..||||.:     ||  :::.:..:.....:..:||
Mouse   474 WGTPFLKEGASEEEINLSTMMMKFWGNFARNGNPNGEGLPHWPEYGEKESYLQIGATTQQAQRLK 538

  Fly   556 CLNIS--DELKVIDVPDLKK 573
            ...::  ..|:.::|.:..|
Mouse   539 DKEVAFWTSLRAMEVGEATK 558

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	160/579 (28%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	47/125 (38%)
Ces1a	NP_001013786.2	Esterase_lipase	25..536	CDD:238191	160/577 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832962
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740