DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces1c

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_006255234.2	Gene:	Ces1c / 24346	RGDID:	2571	Length:	551	Species:	Rattus norvegicus

Alignment Length:	570	Identity:	173/570 - (30%)
Similarity:	257/570 - (45%)	Gaps:	108/570 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYG--QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |...||.||.|.:.| |..|:.|  |....|..:||||||:|.||:..|:|.|.|:.|::.|:..
  Rat    23 SSPPVVDTTKGKVLG-KYVSLEGFTQPVAVFLGVPFAKPPLGSLRFAPPEPAEPWSFVKNTTTYP 86

  Fly    92 PKPLQKHFVFEM-------------TDGSEDCLYLNVY-----TKNLYPTKPMPVMVWIYGGGFQ 138
            |...|...|.::             .:.||||||||:|     |||    ..:||||||:|||..
  Rat    87 PMCSQDGVVGKLLADMLSTGKENIPLEFSEDCLYLNIYSPADLTKN----SRLPVMVWIHGGGLI 147

  Fly   139 FGEASRECYSPDYL-LREDVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDPELDV 199
            .|.||.  ||...| ..|:|||::|.||||..|   |.|:..:
  Rat   148 IGGASP--YSGLALSAHENVVVVTIQYRLGIWGLFSTGDEHSR---------------------- 188

  Fly   200 PGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNT 264
             ||....||:.|||||:.|.:.|||:..::||||:|||..||..::::.....|||:||..||..
  Rat   189 -GNWAHLDQLAALRWVQDNIANFGGNPDSVTIFGESAGGVSVSVLVLSPLAKNLFHRAISESGVV 252

  Fly   265 LSPWAVTPQRNWPYRLAVQAGYAGENNTRD--VWEFLKNAKGSEIIKANGELCIDEEKKERIGFS 327
            |:  ....::|......:.|..:|.|||..  :.:.|:....:|::    ||.:..:..     |
  Rat   253 LT--TNLDKKNTQAVAQMIATLSGCNNTSSAAMVQCLRQKTEAELL----ELTVKLDNT-----S 306

  Fly   328 FGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNE---------GLLLYSETKTNPKCL 383
            ...||:     ..|:||.|.|::.....|.:|.|:|....|         |.|| ||.:.|.|..
  Rat   307 MSTVID-----GVVLPKTPEEILTEKSFNTVPYIVGFNKQEFGWIIPTMMGNLL-SEGRMNEKMA 365

  Fly   384 NELDDCRFVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTV 448
            :.|.. ||...:.::.....|:..:|   ||    |...|: ......|.|.|..:|..|  ..:
  Rat   366 SSLLR-RFSPNLNISESVIPAIIEKY---LR----GTDDPA-KKKELLLDMFSDVFFGIP--AVL 419

  Fly   449 LSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYK 513
            :||......||||:|.|.:.....:..|    .:.|:|. |||::..:|.....:  :..:.|..
  Rat   420 MSRSLRDAGAPTYMYEFQYRPSFVSDQR----PQTVQGD-HGDEIFSVFGTPFLK--EGASEEET 477

  Fly   514 CIERLV-GLWTHFAACGNPNFD-----PE--QEDLWQPVDPAAVEKHQLK 555
            .:.:|| ..|.:||..||||.:     ||  |::.:..:.....:..:||
  Rat   478 NLSKLVMKFWANFARNGNPNGEGLPHWPEYDQKEGYLQIGATTQQAQKLK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	170/564 (30%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	49/130 (38%)
Ces1c	XP_006255234.2	COesterase	24..534	CDD:395084	172/569 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810