DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Cel

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_058693.2	Gene:	Cel / 24254	RGDID:	2331	Length:	612	Species:	Rattus norvegicus

Alignment Length:	548	Identity:	153/548 - (27%)
Similarity:	224/548 - (40%)	Gaps:	124/548 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 VSTTYGPIKGVKRK--SIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQ 96
            |.|..|.::||.:|  .:.|.|...|:.||||.....|    .||....|......|....:.||
  Rat    26 VYTEGGFVEGVNKKLSLLGGDSVDIFKGIPFATAKTLE----NPQRHPGWQGTLKATDFKKRCLQ 86

  Fly    97 KHFVFEMTDGSEDCLYLNVYT----KNLYPTKPMPVMVWIYGGGFQFGEASRECYSPDYL----- 152
            .....:.|.|.|||||||::.    |.:  :..:|||||||||.|..|......:..:||
  Rat    87 ATITQDDTYGQEDCLYLNIWVPQGRKQV--SHDLPVMVWIYGGAFLMGSGQGANFLKNYLYDGEE 149

  Fly   153 --LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWV 215
              .|.:|:|::.|||:|||                  |||...|..|  |||.||:||.:|:.||
  Rat   150 IATRGNVIVVTFNYRVGPL------------------GFLSTGDANL--PGNFGLRDQHMAIAWV 194

  Fly   216 KANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRN---WP 277
            |.|.:.||||..||||||:|||:|||....::....||..:||..||..|||||:  |.|   |.
  Rat   195 KRNIAAFGGDPDNITIFGESAGAASVSLQTLSPYNKGLIRRAISQSGVALSPWAI--QENPLFWA 257

  Fly   278 YRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSHCV- 341
            ..:|.:.|...|:..                |..|.|.|.:.:...:.:......:.|...|.:
  Rat   258 KTIAKKVGCPTEDTA----------------KMAGCLKITDPRALTLAYRLPLKSQEYPIVHYLA 306

  Fly   342 ---------VPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFV---VP 394
                     :|..||.:...|  .:|..:.|                   :|::|...|.   ||
  Rat   307 FIPVVDGDFIPDDPINLYDNA--ADIDYLAG-------------------INDMDGHLFATVDVP 350

  Fly   395 IELNMDRESALCREY--------------GDQLRQCYYGD---KTPSLDTLHEYLQMVSHE---Y 439
             .::..::.....::              |.|.....|.:   :.||.:.:.:  .:|:.|   .
  Rat   351 -AIDKAKQDVTEEDFYRLVSGHTVAKGLKGTQATFDIYTESWAQDPSQENMKK--TVVAFETDIL 412

  Fly   440 FWFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARK 504
            |..|....:.....:|:||.||.|.|...|:       :....|..|..|.|||.|:|....|..
  Rat   413 FLIPTEMALAQHRAHAKSAKTYSYLFSHPSR-------MPIYPKWMGADHADDLQYVFGKPFATP 470

  Fly   505 LKNHTREYKCIERLVGLWTHFAACGNPN 532
            |....::....:.::..||:||..|:||
  Rat   471 LGYRAQDRTVSKAMIAYWTNFAKSGDPN 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	153/548 (28%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	51/132 (39%)
Cel	NP_058693.2	COesterase	26..542	CDD:278561	153/548 (28%)
		Aes	<118..>247	CDD:223730	63/148 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..612
		4 X 11 AA tandem repeats, O-glycosylated region	556..599
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.750