DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces4a

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_666325.2	Gene:	Ces4a / 234677	MGIID:	2384581	Length:	563	Species:	Mus musculus

Alignment Length:	603	Identity:	170/603 - (28%)
Similarity:	263/603 - (43%)	Gaps:	132/603 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPK 93
            :::.::.|.:|.::| |:..:.......|..|||:|||||..|:..|:||..|..:|..|:..|.
Mouse    31 TKEPLLITKHGILQG-KQVHVGDTPIQVFLGIPFSKPPVGTRRFAPPEPPLPWNGIRDATTYPPS 94

  Fly    94 PLQK-------------------HFVFEMTDGSEDCLYLNVYTKNLYPTKP-MPVMVWIYGGGFQ 138
            .||:                   ||       ||||||||||...|.|..| :|||||..||.|.
Mouse    95 CLQESWGQILSMYLNTRKQYKWLHF-------SEDCLYLNVYAPVLAPGAPLLPVMVWFPGGAFL 152

  Fly   139 FGEASRECYSPDYL-LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGN 202
            .|.||  .|....| .|..||::.:.||||.||          .|:..          .....||
Mouse   153 AGSAS--TYEGSELAARGKVVLVFLQYRLGILG----------FFSTG----------NSHARGN 195

  Fly   203 AGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSP 267
            .||.||:.|||||:.|...||||..::|:||.|||:.||..:|::....||||:||..||..:..
Mouse   196 WGLLDQIAALRWVQENIEAFGGDPDSVTLFGQSAGAMSVSGLMVSPLAQGLFHQAISQSGTAVLK 260

  Fly   268 WAVTPQRNWPY----RLAVQAGYAGENNTRDVWEFLKNAKGSEI---------IKANGELCIDEE 319
            ..:||.   |.    ::|..|| ...|:|:.:.|.|::....|:         .:||..    ::
Mouse   261 AFITPD---PLTSAKKIAHLAG-CDHNSTKVMVECLRSLSAEEVTLVSKRMSFFQANSH----KD 317

  Fly   320 KKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNE----GLLLYSETKTNP 380
            .||.:.| ..||::     ..|.|:.|:.::.......:|.:: ||:|.    .|....:.:.|.
Mouse   318 PKEIVWF-LSPVVD-----GVVFPEDPVVLLTRGQVKPVPYLL-GVNNAEFEWNLPFLMKIQLNQ 375

  Fly   381 KCLNELDDCR----FVVPIELNMDRESALCREY-GDQLRQCYYGDKTPSLDTLHEY-------LQ 433
            :.:|:.:..:    |.|.:.:..::...:.||| .|.:..             |::       :.
Mouse   376 RMMNQTNINKILWSFNVLLNITKEQVPVVAREYLNDAISN-------------HDWKMFRNRLID 427

  Fly   434 MVSHEYFWFPIYRTVLSRLQYARSA--PTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYL 496
            ::....|   :|.| |...:|.|.|  |.|||.|    ||.....|:.  |...|..|||:||||
Mouse   428 LIGDATF---VYAT-LQAARYHRDAGSPVYLYEF----KHHASSGIII--KPYNGADHGDELSYL 482

  Fly   497 FYNSLAR-KLKNHTREYKCIERLVGLWTHFAACGNPN---------FDPEQEDLWQPVDPAAVEK 551
            |.:..:: ......:|:..  :::..|.:||..||||         ||.:::.|....|.....|
Mouse   483 FGSPFSKGSSAGEEKEFSL--QMMKYWANFAHTGNPNGEKLPYWPRFDKDEKYLQLDFDTRVGVK 545

  Fly   552 HQLKCLNISDELKVIDVP 569
            .:.|.:....:|:....|
Mouse   546 LKEKKMAFWSQLRQSQKP 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	167/583 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	48/123 (39%)
Ces4a	NP_666325.2	COesterase	30..554	CDD:278561	168/592 (28%)
Ces4a	NP_666325.2	Aes	<128..>272	CDD:223730	64/168 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832845
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740