DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est9 and Ces2c

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_663578.1	Gene:	Ces2c / 234671	MGIID:	2385905	Length:	561	Species:	Mus musculus

Alignment Length:	565	Identity:	154/565 - (27%)
Similarity:	230/565 - (40%)	Gaps:	128/565 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PIKGVKRKSIYGQ---------SYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPL 95
            ||:......|.|.         ...:|..|||||||||.||:..|:.||.|:.||..|:.....|
Mouse    34 PIRNTHTGQIQGSLIHVKDTKAGVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDGTAHPAMCL 98

  Fly    96 QK------------HFVFEMTDGSEDCLYLNVYT-KNLYPTKPMPVMVWIYGGGFQFGEASRECY 147
            |.            ..:......||||||||:|| .:.:....:||||||:||....|.||  .:
Mouse    99 QNLDMLNEAGLPDMKMMLSSFPMSEDCLYLNIYTPAHAHEGSNLPVMVWIHGGALVIGMAS--MF 161

  Fly   148 SPDYL-LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLA 211
            ....| :.||:||::|.||||.|                  ||....|..  ..||.|..||..|
Mouse   162 DGSLLTVNEDLVVVTIQYRLGVL------------------GFFSTGDQH--ARGNWGYLDQAAA 206

  Fly   212 LRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNW 276
            ||||:.|.:.|||:...:||||:|||..||...:::..:.||||.||..||..|.|
Mouse   207 LRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVALLP--------- 262

  Fly   277 PYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEE--------KKERIGFSFGPVIE 333
                             |:.........:.:.|.:|...:|.:        |.|....:...|.:
Mouse   263 -----------------DLISETSEMVSTTVAKLSGCEAMDSQALVRCLRGKSEAEILAINKVFK 310

  Fly   334 --PYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNE------------GLLLYSETKTNPKCLN 384
              |.|......|:.|.|::.:...:.:|.|| ||:|:            ..::...|:.|.:.:.
Mouse   311 MIPAVVDGEFFPRHPKELLASEDFHPVPSII-GVNNDEFGWSIPVVMGSAQMIKGITRENLQAVL 374

  Fly   385 ELDDCRFVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLH-EYLQMVSHEYFWFPIYRTV 448
            :....:.::|.|.:            |.|.:.|.|| |....||. ::.:|:....|..|    .
Mouse   375 KDTAVQMMLPPECS------------DLLMEEYMGD-TEDAQTLQIQFTEMMGDFMFVIP----A 422

  Fly   449 LSRLQYARS-APTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREY 512
            |....:.|| ||.|.|.|.....:|..:|    ...|:.. |.|::.::|.:.......:.|.|.
Mouse   423 LQVAHFQRSHAPVYFYEFQHPPSYFKDVR----PPHVKAD-HADEIPFVFASFFWGMKLDFTEEE 482

  Fly   513 KCI-ERLVGLWTHFAACGNPN---------FDPEQEDLWQPVDPA 547
            :.: .|::..|.:||..||||         .|.:::.|...:.||
Mouse   483 ELLSRRMMKYWANFARHGNPNSEGLPYWPVMDHDEQYLQLDIQPA 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	154/565 (27%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	46/123 (37%)
Ces2c	NP_663578.1	COesterase	31..540	CDD:278561	154/565 (27%)
		Aes	<130..>233	CDD:223730	47/124 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832724
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740