DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est9 and Ces1f

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_659179.1	Gene:	Ces1f / 234564	MGIID:	2142687	Length:	561	Species:	Mus musculus

Alignment Length:	572	Identity:	165/572 - (28%)
Similarity:	237/572 - (41%)	Gaps:	152/572 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYG--QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |...||.|.:|.:.| |..::.|  |....|..|||||||:|.||:..|||.|.|:.|::.|:..
Mouse    21 SSPPVVDTAHGKVLG-KHVNVEGFSQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWSSVKNATTYP 84

  Fly    92 PKPLQK------------------HFVFEMTDGSEDCLYLNVYT-----KNLYPTKPMPVMVWIY 133
            |...|.                  |..|     ||||||||:||     ||    ..:||||||:
Mouse    85 PMCSQDAARGQAVNDLITNRKEKIHLEF-----SEDCLYLNIYTPADFSKN----SRLPVMVWIH 140

  Fly   134 GGGFQFGEASR------ECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCL 192
            |||.:.|.||.      ..|       |:|||::|.|||                  |:.||...
Mouse   141 GGGLKLGGASSFDGRALSAY-------ENVVVVAIQYRL------------------SIWGFFST 180

  Fly   193 DDPELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKA 257
            .|..  ..||.|..|||.||.||:.|.:.||||..::||||:|||..||..::::..:..|||:|
Mouse   181 GDEH--SRGNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGYSVSILILSPLSKNLFHRA 243

  Fly   258 ICMSGNTLSPWAVTPQ-RNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEII-----KAN-GELC 315
            |..||....|...|.. |....::||.||.  :..|..|.......|..|.:     |.| .:|.
Mouse   244 ISESGVAFIPGMFTKDVRPITEQIAVTAGC--KTTTSAVIVHCMRQKTEEELLEIMHKLNLYKLS 306

  Fly   316 IDEEKKERIGFSFGPVIEPYVTS---HCVVPKKPIEMMRTAWSNNIPLIIGGVSNE-GLLLYSET 376
            :..:.|..         :.:|||   ..|:||.|.|::.....|.:|.|:|....| |.||.:.|
Mouse   307 LQGDTKNS---------DQFVTSVLDGVVLPKDPKEILAEKNFNTVPYIVGINKQECGWLLPTMT 362

  Fly   377 KTNPKCLNELDDCRFVVPIELNMDRESALC--------------------REY------GDQLRQ 415
            .              .:|.::.:|::.|:.                    .:|      .||:|:
Mouse   363 G--------------FLPADVKLDKKKAIALLEQFASMTGIPEDIIPVAVEKYTKGSDDPDQIRE 413

  Fly   416 CYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSC 480
                   ..||.:.:..         |.:...::||......||||:|.:.:.....:..|
Mouse   414 -------GVLDAMGDVA---------FGVPSVIVSRGHRDTGAPTYMYEYQYYPSFSSPQR---- 458

  Fly   481 GKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAACGNPN 532
            .|.|.|. |.||:..:|...:.|:..:. .|....:.::..|.:||..||||
Mouse   459 PKNVVGD-HADDVYSVFGAPILREGASE-EEINLSKMVMKFWANFARNGNPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	164/568 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	49/132 (37%)
Ces1f	NP_659179.1	COesterase	24..545	CDD:278561	164/569 (29%)
		Aes	<121..>225	CDD:223730	51/134 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255\|PROSITE-ProRule:PRU10138	558..561
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832963
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740