Protein Alignment alpha-Est9 and NLGN4Y

DIOPT Version :10

• Sequence 1: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001352513.1
• Gene: NLGN4Y / 22829
• HGNCID: 15529
• Length: 836
• Species: Homo sapiens
• Alignment Length: 663
• Identity: 178/663 - (26%)
• Similarity: 267/663 - (40%)
• Gaps: 183/663 - (27%)

  Fly    12 IGLKMVDFKVQQRRYRTSEKTVVSTTYGPIKGVKR---KSIYG--QSYFSFERIPFAKPPVGELR 71
            |...::|.:.|.        .||:|.||.|:|::.   ..|.|  :.|..   :|:|.||.||.|
Human    34 IKFTLIDSQAQY--------PVVNTNYGKIQGLRTPLPSEILGPVEQYLG---VPYASPPTGERR 87

  Fly    72 YKAPQPPEVWTEVRSCTSQG---PKPLQKHFVFE--------------MT---DGSEDCLYLNVY 116
            ::.|:.|..||.:|:.|...   |:.|.:.|:..              ||   |.:|||||||:|
Human    88 FQPPESPSSWTGIRNATQFSAVCPQHLDERFLLHDMLPIWFTTSLDTLMTYVQDQNEDCLYLNIY 152

  Fly   117 T-----------------------KNLY-PTKPMPVMVWIYGGGFQFGEASR------ECYSPDY 151
            .                       |::: .....||||:|:||.:..|..:.      ..|.
Human   153 VPMEDGTNIKRNADDITSNDHGEDKDIHEQNSKKPVMVYIHGGSYMEGTGNMIDGSILASYG--- 214

  Fly   152 LLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVK 216
                :|:||:||||||.|                  |||...|..  ..||.||.||:.||||::
Human   215 ----NVIVITINYRLGIL------------------GFLSTGDQA--AKGNYGLLDQIQALRWIE 255

  Fly   217 ANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYRLA 281
            .|...||||...:||||..||::.|..:.::..:.|||.|||..||..||.|||..|   |.:..
Human   256 ENVGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAVNYQ---PAKYT 317

  Fly   282 -VQAGYAGEN--NTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVP 343
             :.|...|.|  :|.|:.|.|||....|:|:       ..........:|||||:     ..|:|
Human   318 RILADKVGCNMLDTTDMVECLKNKNYKELIQ-------QTITPATYHIAFGPVID-----GDVIP 370

  Fly   344 KKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPIELNMDRESALCRE 408
            ..|..:|......|..:::|....|||....         ..:|:...|.|.:.:....:.:...
Human   371 DDPQILMEQGEFLNYDIMLGVNQGEGLKFVD---------GIVDNEDGVTPNDFDFSVSNFVDNL 426

  Fly   409 YG-----DQLRQCY------YGDKTPSLDTLHEYLQMVSHEYFWF-PIYRTVLSRLQYARSAPTY 461
            ||     |.||:..      :.|| .:.:|..:.|..:..::.|. |...|.....||  .:|||
Human   427 YGYPEGKDTLRETIKFMYTDWADK-ENPETRRKTLVALFTDHQWVAPAVATADLHAQY--GSPTY 488

  Fly   462 LYRFDFDSKHFNHLRILSCGKKVR----GTCHGDDLSYLFYNSLARKLKNHTREYKC-------- 514
            .|.|      ::|     |..:::    .:.|||::.|:|    ...:...|..:.|
Human   489 FYAF------YHH-----CQSEMKPSWADSAHGDEVPYVF----GIPMIGPTELFSCNFSKNDVM 538

  Fly   515 IERLV-GLWTHFAACGNPNFDPEQED--------------LWQPVDPAAVEKHQLKCLNISDELK 564
            :..:| ..||:||..|:|| .|..:|              .|...:|    |.|| .|:|..:.:
Human   539 LSAVVMTYWTNFAKTGDPN-QPVPQDTKFIHTKPNRFEEVAWSKYNP----KDQL-YLHIGLKPR 597

  Fly   565 VIDVPDLKKLMVW 577
            |.|.....|:..|
Human   598 VRDHYRATKVAFW 610

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	32..577	CDD:395084	174/641 (27%)
NLGN4Y	NP_001352513.1	COesterase	44..610	CDD:395084	175/651 (27%)