Protein Alignment alpha-Est9 and CES5A

DIOPT Version :10

• Sequence 1: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001177087.1
• Gene: CES5A / 221223
• HGNCID: 26459
• Length: 604
• Species: Homo sapiens
• Alignment Length: 583
• Identity: 162/583 - (27%)
• Similarity: 239/583 - (40%)
• Gaps: 147/583 - (25%)

  Fly    35 STTYGPIKGVKRKSIYGQ--SYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQ- 96
            :|..|.|:| |:.::.|.  ....|..:|||.||:|.||:..|||...|..:|..||.....||
Human    63 NTRLGWIQG-KQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPASPWDNLREATSYPNLCLQN 126

  Fly    97 -------KHFV---FEMTDGSEDCLYLNVYTKNLYPT-KPMPVMVWIYGGGFQFGEASRECYSPD 150
                   :|.:   :.....||||||||:|......| ..:||:||..||.|:.|.||  .:...
Human   127 SEWLLLDQHMLKVHYPKFGVSEDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSAS--IFDGS 189

  Fly   151 YLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRW 214
            .|.. |||:|:.:.||||..|. ..||                   :...|||...||||.||.|
Human   190 ALAAYEDVLVVVVQYRLGIFGF-FTTW-------------------DQHAPGNWAFKDQVAALSW 234

  Fly   215 VKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWPYR 279
            |:.|...||||.:::||||:|||:.||..::::....|||||||..||..:.|:...........
Human   235 VQKNIEFFGGDPSSVTIFGESAGAISVSSLILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSED 299

  Fly   280 LAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSHCVVPK 344
            |.|.|.:.| ||..|....|:..:    .|.:.||....:|.:    ||..|::     ....|.
Human   300 LQVVAHFCG-NNASDSEALLRCLR----TKPSKELLTLSQKTK----SFTRVVD-----GAFFPN 350

  Fly   345 KPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPIELNMDRESALCREY 409
            :|::::.......||.|| ||:|.                   :|.|::|::...:..|...:..
Human   351 EPLDLLSQKAFKAIPSII-GVNNH-------------------ECGFLLPMKEAPEILSGSNKSL 395

  Fly   410 GDQLRQCYYGDKTPSLDTLH---EYLQMVSHEYF--------------------WFPIYRTVLSR 451
            ...|.|          :.||   :||.:|::|||                    :|.:...:.:|
Human   396 ALHLIQ----------NILHIPPQYLHLVANEYFHDKHSLTEIRDSLLDLLGDVFFVVPALITAR 450

  Fly   452 LQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTC------------HGDDLSYLFYNSLAR- 503
            ......||.|.|.|    :|             |..|            |.|::.::|..:..:
Human   451 YHRDAGAPVYFYEF----RH-------------RPQCFEDTKPAFVKADHADEVRFVFGGAFLKG 498

  Fly   504 ---KLKNHTREYKCIER-LVGLWTHFAACGNPNFDPEQEDLWQPVDPA--AVEKHQLKCLNIS 560
               ..:..|.|.|.:.| ::..|..||..||||  .....||    ||  ..|::....||:|
Human   499 DIVMFEGATEEEKLLSRKMMKYWATFARTGNPN--GNDLSLW----PAYNLTEQYLQLDLNMS 555

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	32..577	CDD:395084	162/583 (28%)
CES5A	NP_001177087.1	COesterase	58..568	CDD:395084	162/583 (28%)