Protein Alignment alpha-Est9 and cest-2.2

DIOPT Version :10

• Sequence 1: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001256567.1
• Gene: cest-2.2 / 179917
• WormBaseID: WBGene00013874
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 615
• Identity: 144/615 - (23%)
• Similarity: 231/615 - (37%)
• Gaps: 179/615 - (29%)

  Fly    29 SEKTVVSTTYGPIKGVKRKSIY----GQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEV----- 84
            |.|..:|:..|.|:|....:.|    .|:...|..:|:.:||||.||::.|:||:.|..|
 Worm    17 STKVKLSSRTGTIEGRTLTASYSPLGNQTGIVFFGVPYVEPPVGNLRFRKPRPPKPWDGVLEAKE 81

  Fly    85 --RSCTSQGPKPLQKHFVFEMTDG--SEDCLYLNVYTKNLY--PTKPMPVMVWIYGGGFQFGEAS 143
              .:|.|.     ||........|  ||||||.||:| |.|  ..|...||:.|:||.|....||
 Worm    82 YKAACMSD-----QKKTYKNGVGGPVSEDCLYANVFT-NQYCLEHKNCSVMLTIHGGRFVIESAS 140

  Fly   144 RECYSPDYLLR------EDVVVISINYRLGPL------GTNDDTWKKKHIFNISLPGFLCLDDPE 196
              .|.|:.::.      .::||::.|||||..      |.|.||
 Worm   141 --AYDPEIIINNFVGQGRNIVVVTFNYRLGLFGLGMLNGDNQDT--------------------- 182

  Fly   197 LDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMS 261
                 |.||.|.:..:||.:.....||||...||:.|.|||:........:..:.||.|:.|.||
 Worm   183 -----NFGLYDILEVVRWTRKEIKNFGGDKDRITMQGHSAGAVFTAAFSTSPLSKGLIHQQIIMS 242

  Fly   262 GNTLSPWAVTPQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGF 326
                               |..:..:.::|.:::         :.:.:..|  |:.:|.    ||
 Worm   243 -------------------ASMSNLSKKSNVKEL---------TVVARIVG--CLPDEH----GF 273

  Fly   327 SFGPVIEPYVTSHCVVPKK-------PIEMMRTAWSNNIPLIIGGVSNEGLL-------LYSETK 377
            .....:|......|:..|.       .:.|:|     |....||....:|:.       ||:...
 Worm   274 PKLSNVEVEKAYTCLRSKSAQQILDAQLYMLR-----NTTYYIGQGHIDGIYQVDYPDNLYATNS 333

  Fly   378 TNPKCLN--------ELDDCRFVVPIELNMDRE---SALCREYGDQL--------RQC--YY--G 419
            ..|  :|        ||.|.|::|..:....:|   ..||...|.:|        ::|  :|  |
 Worm   334 IYP--INTMIGTTTAELMDSRYIVDPKNTGKKEILLQNLCEHIGYELYKEPEEFSQKCRNFYKNG 396

  Fly   420 DKTPSL-DTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDFDS-----KHFNHLRIL 478
            :...|| |.:..|...:.            |:.:..::....::|.||:..     |.::
 Worm   397 EDAKSLGDDMEFYYGAIQ------------LANVHSSKDTNVFVYSFDYKEAGNAYKKYD----- 444

  Fly   479 SCGKKVRGTCHGDDLSYLFYNSLAR-KLKNHTREYKCIERLVGLWTHFAACGNPNFDPEQEDLWQ 542
                |.....||:|.:|.|..:... ..|::..||    ...|::..|...|:|:  |.::..|.
 Worm   445 ----KSLSPKHGEDFAYAFGTNRGNFSTKDYVIEY----IYSGMFADFVNFGDPS--PLEDQEWA 499

  Fly   543 PVDPAAVEKHQLKCLNISDELKVIDVPDLK 572
            ...|   ||.:...::..   |...:|.:|
 Worm   500 QYTP---EKREYFLIDFD---KNFTMPGMK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	32..577	CDD:395084	142/612 (23%)
cest-2.2	NP_001256567.1	alpha/beta hydrolases	25..534	CDD:473884	141/607 (23%)