DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and cest-35.1

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_504400.1	Gene:	cest-35.1 / 178912	WormBaseID:	WBGene00015067	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	542	Identity:	153/542 - (28%)
Similarity:	236/542 - (43%)	Gaps:	114/542 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVSTTYGPIKGVKRKSIYG------QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |::.:.|||:|    :||.      ..|..   |||||.|:||||:|.....|.|||...|...|
Worm    16 VLNASCGPIRG----NIYEHDDKIVDGYLG---IPFAKAPIGELRFKKSVEAEKWTEPLDCYKYG 73

  Fly    92 PKPLQKHFVFEM--------TDGSED-CLYLNVYT---KNLYPTKPMPVMVWIYGGGFQFGEASR 144
            |...|...:..|        .:.:|| ||.|||:.   |:......:||:|:.|||||:.|.:|
Worm    74 PGCPQSGALGAMIVPQASAIREFAEDNCLTLNVFAPKWKSAEFPNGLPVIVYFYGGGFEVGFSS- 137

  Fly   145 ECYSPDYLLR-----EDVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDPELDVPG 201
              ...||.|.     :||::::.|||:||||   |.||..:                       |
Worm   138 --MFDDYSLTGTLPLKDVILVTPNYRIGPLGFFATGDDVSR-----------------------G 177

  Fly   202 NAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLS 266
            |.||.||.|||:||:.:...||||.:|:||.|.|||.|||.::.::...:..|||.|.|||....
Worm   178 NWGLWDQALALQWVQKHIKSFGGDPSNVTISGTSAGGASVDFLSLSPHANKYFHKFIPMSGAATC 242

  Fly   267 PWAVTPQ--RNWPYR-LAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIG-FS 327
            |:.:..:  ....:| .|...|||| |::..:..:.::......:||.|      .|....| ||
Worm   243 PFGIRSKDVEGLIFREFAKHHGYAG-NDSESLLHWYQSQDAEIFLKAEG------FKYPASGMFS 300

  Fly   328 FGPVIE----PYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGL---LLYSETKTNPKCLNE 385
            |.|..:    |          ||.:.:|.. :..:..|:.....|||   ..|...|:..:.|..
Worm   301 FVPNYDGDFFP----------KPFDELRKE-APKLDAIVSVAEYEGLGFEEFYPGQKSPQEVLTA 354

  Fly   386 LDDCRFVVPIELNMDRESALCREYGDQLR--QCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTV 448
                  .:..|:..:||..:.:.....|.  :...|:|...     :.:::....||...::.||
Worm   355 ------ALGPEVVRNREEVVKKAVEAYLENIEDKSGEKIGK-----KLVEIFGDYYFSVGVFDTV 408

  Fly   449 LSRLQYARSAPTYLYRFDFDSKHFNHLRILSCG--KKVRGTCHGDDLSYLFYNSLARKLKNHTRE 511
            .|..:|..:  .||..|::    ||....:..|  :......||.|:.|:    |...:...::|
Worm   409 RSLAKYGNN--VYLSSFNY----FNPETPIMFGENRPFNAASHGCDIRYI----LGDGIGEFSKE 463

  Fly   512 YKCIERLVGLW-THFAACGNPN 532
            .:.:..::|.: |:||..||||
Worm   464 DRKVMDMMGTYLTNFAKYGNPN 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	153/542 (28%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	47/132 (36%)
cest-35.1	NP_504400.1	COesterase	14..516	CDD:278561	153/542 (28%)
cest-35.1	NP_504400.1	Aes	<106..>214	CDD:223730	48/133 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740