DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est9 and cest-32

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_504397.1	Gene:	cest-32 / 178909	WormBaseID:	WBGene00016862	Length:	545	Species:	Caenorhabditis elegans

Alignment Length:	556	Identity:	143/556 - (25%)
Similarity:	235/556 - (42%)	Gaps:	115/556 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVSTTYGPIKGVKRKSIYG------QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |::.:.||:.|    :||.      ..|..   |||||.|:.|||:|.|...|.||:..:|...|
Worm    16 VLNASCGPVIG----NIYRHDDKIVNGYLG---IPFAKAPICELRFKKPVEAEKWTKPLNCHKYG 73

  Fly    92 PK-PLQKHFVFEMTD------GSEDCLYLNVYTKNL----YPTKPMPVMVWIYGGGFQFGEASRE 145
            |. |...|.:..:..      ..::||.||::..:.    :| ..:|:||:.:||||:.|.:|
Worm    74 PGCPQSGHMISNLLPPGYREFAEDNCLNLNIFAPSWKSEEFP-NGLPIMVYFHGGGFEIGFSS-- 135

  Fly   146 CYSPDYLLR-----EDVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDPELDVPGN 202
             ...||.|.     :||:|::.|||:||||   |.|:..:                       ||
Worm   136 -MFDDYSLSGTLPLKDVIVVTANYRVGPLGFMTTGDEVSR-----------------------GN 176

  Fly   203 AGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSP 267
            .||.||.|||:||:.:...|||:...:|:.|.|||..|...:.::..::.|||:.:.|||:....
Worm   177 YGLWDQTLALKWVQEHIKSFGGNPNIVTVCGTSAGGVSAGLLALSPHSNKLFHRFMAMSGSAFCE 241

  Fly   268 WAVTPQ-------RNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIG 325
            :::..:       ||:    |...||.|| ::..:.|:.|    |:.:....|....|:|..  |
Worm   242 FSIRTKEQEAEIFRNF----AKHHGYEGE-DSESLLEWYK----SQPLSKFQETATFEKKAS--G 295

  Fly   326 F-SFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDC 389
            | :|.|..:     ....||...|:.|.|...:....:......|.|...:::.     |::|
Worm   296 FLTFIPNFD-----GDFFPKPFDELSREAPKLDAMATVDEYEGLGFLTMFQSRR-----NDMD-- 348

  Fly   390 RFVVP-------IELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRT 447
              ::.       :|..:|.:..:...|...:      ||..........:|::|..:|......|
Worm   349 --IIKSSFGSDVVENAVDVQKRIMEFYMKNI------DKNDDKAVEKRLIQLISDSWFNIGALET 405

  Fly   448 VLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREY 512
            |.:..:|..:|  ||..||:.:...|.  ..:.....:...||.:|.|:....:. |......|:
Worm   406 VKTSTKYGSNA--YLGSFDYYNMGSND--PYATWFPFKAANHGSELKYMLGEGMG-KFSPIEEEF 465

  Fly   513 KCIERLVGLWTHFAACGNPN--FDPEQEDLWQPVDP 546
            |.|:.:..|..:|...||||  ..||   ||:...|
Worm   466 KVIDMMGTLTANFVKYGNPNGINGPE---LWKKYTP 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	143/556 (26%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	42/133 (32%)
cest-32	NP_504397.1	COesterase	15..516	CDD:278561	143/556 (26%)
cest-32	NP_504397.1	Aes	<104..>227	CDD:223730	45/149 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157259
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.740