DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and cest-12

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_499576.4	Gene:	cest-12 / 176642	WormBaseID:	WBGene00013540	Length:	850	Species:	Caenorhabditis elegans

Alignment Length:	572	Identity:	134/572 - (23%)
Similarity:	214/572 - (37%)	Gaps:	141/572 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 QRRYRTSEKTVVSTTYGPIKGVK------RKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVW 81
            |.:.:.|....||.:.|.::|.:      :..:|.....:|..||:.:.|||.||.:.|||...:
Worm    26 QNQNQQSNYVTVSCSQGSVQGRQVNLGNDQSQLYSGQANAFTGIPYCQAPVGNLRLQPPQPLNQF 90

  Fly    82 -TEVRSCTSQGPKPLQKHFVFEMTDG---SEDCLYLNVYTKNLYPTKP-MPVMVWIYG-GGFQFG 140
             |.:...|...||..|      :..|   :||||||||||.....|.. :.|:|.|.| .||..|
Worm    91 NTTLHDATYFRPKCPQ------LNAGGPTNEDCLYLNVYTPQAGNTNANLSVLVLIDGSNGFSNG 149

  Fly   141 --EASRECYSPDYLLREDVVVISINYRLGPLG-----TNDDTWKKKHIFNISLPGFLCLDDPELD 198
              :.::|......|::..:||:::.||:|.||     ||                         .
Worm   150 GCDQNQEKGIISNLVQRQIVVVTMQYRIGALGFFTTYTN-------------------------S 189

  Fly   199 VPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGN 263
            |..|.|:.|||.|:||:|.....|||:...||:.|...|:.:|....::..:..||::||..||:
Worm   190 VQSNLGMLDQVQAMRWIKTEIVNFGGNPNQITVAGQDDGACAVSAHCLSPMSQNLFNQAIVQSGS 254

  Fly   264 TLSPWAVTP------------------QRNWPYRLAVQAGYAGENN------------------- 291
            ..|.:..||                  |.|..|.   .|||  :||
Worm   255 VYSCYNPTPAVPTNPQVQVTTPRPMYDQSNTGYG---NAGY--QNNYGYQPQPITSTSSYNSANA 314

  Fly   292 ----------------TRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSHC 340
                            :.|.|   .|.:...|........:|....::.|   ||.....:....
Worm   315 QYDDPSQQLAQTLCNISPDQW---NNGQTQNIQNCMKNYTVDFFVNQQPG---GPNATWMIVRDT 373

  Fly   341 VVPKKPIEMMRTAWSNNIPLIIGGVSNEGL-----LLYSETKTNPKCLNELDDCRFVVPIELNMD 400
            ......|:.:.|. ..|||:|||.|.:|..     |:.:...::|   |.|||..|      :..
Worm   374 SFLPGSIDSLTTR-RPNIPIIIGTVQDEDADYAFKLINTGKGSDP---NNLDDWIF------DFA 428

  Fly   401 RESALCREYGDQLRQCY---YGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPT-Y 461
            |::.|.:...:|:....   ||..|.:|.   :....|:.:|......:.|.::.|..:...| .
Worm   429 RKNKLNQTQANQVSNIISNNYGVNTGALG---QQGAQVNSQYQGSGTGQQVNNQYQNTQGQQTNN 490

  Fly   462 LYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYK 513
            .|::|...:..|:.     |....|...|...:|...|...:.::.....|:
Worm   491 QYQYDQGGQQTNNQ-----GAYYGGVVAGQQTTYQNQNQNQQGVQRDQGSYQ 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	132/562 (23%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	38/130 (29%)
cest-12	NP_499576.4	Abhydrolase	37..>400	CDD:389770	103/405 (25%)
cest-12	NP_499576.4	Abhydrolase	<678..774	CDD:389770
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.900