DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and cest-27

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	604	Identity:	167/604 - (27%)
Similarity:	252/604 - (41%)	Gaps:	142/604 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQK 97
            |...|.||||||..:...|.....|..||:|:||:|.||:|.|.....|||...|...||:..|.
Worm    27 VHDATCGPIKGVGYEQEDGSVVEGFLGIPYAEPPIGALRFKKPVAHRKWTEPLDCVRFGPRSPQN 91

  Fly    98 -----HFVFEMTDGSEDCLYLNVYT----KNLYPTKPMPVMVWIYGGGFQFGEASR-ECYS-PDY 151
                 .||..:....|.||.|||:|    .|.:| ...||||:|:||||....:|. .|.| ...
Worm    92 DELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWP-DGFPVMVFIHGGGFAVHSSSNYGCASIARN 155

  Fly   152 LLREDVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALR 213
            |..:||||::||||||.||   |.|:..:                       ||.||.||..||.
Worm   156 LCTKDVVVVTINYRLGVLGFFTTGDEVCR-----------------------GNLGLWDQTAALE 197

  Fly   214 WVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAV---TPQRN 275
            ||:.|...|.||..|:||||.|||.|||..:.::..:.|||::||.|:||....:|:   ..|..
Worm   198 WVQENIQSFRGDPDNVTIFGQSAGGASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQ 262

  Fly   276 WPYRLAVQAGYAG-ENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEPYVTSH 339
            .....|...|:.| :|::.|:.:|:......:|     |:.|:.::    ||........|
Worm   263 LSREFARYLGWEGDDNDSEDLLQFIDQQPLYKI-----EMGINPKR----GFKHSQAGSLY---- 314

  Fly   340 CVVPK-------KPIEMMRTAWSNNIPLIIGGVSNEGL--LLYSETKTNPKCLNELDDCRFVVPI 395
             .||.       ||:..:|.. :..:.::.|....|||  :.......||:.:.:.
Worm   315 -FVPNFDGDFFPKPLNQLRKE-APKMQIMTGTTKYEGLFFIALGALSKNPEGIKKF--------- 368

  Fly   396 ELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFW------------------- 441
                         .|...::|.||::.      .:.||||...||.
Worm   369 -------------MGRIFKECDYGERA------DDVLQMVYDFYFKGVHPKDHEKNMHQIVKFIG 414

  Fly   442 -----FPIYR--TVLSRLQYARSAPTYLYRFDF-DSKHFNHLRILSCGKKVRGTCHGDDLSYLFY 498
                 :..||  .:::.||:    ..|.|:||: :|..|...|.|   ....|:.|..::.|:..
Worm   415 DYSINYGTYRLANIMTDLQH----DVYFYQFDYHNSAGFGVFRWL---LPFLGSTHCTEMRYVLG 472

  Fly   499 NSLARKLKNHTREYKCIERLVGLWTHFAACGNPNFDPEQEDLWQPVDPA--------------AV 549
            ..:..|.:.:..:.|.:..:...:|:||..||||.:.::...||..|.|              .|
Worm   473 KGIISKFRPNDNDKKMLHVMTTYFTNFAKYGNPNGENQETGEWQKHDSAHPFRHFKIDLDDSEMV 537

  Fly   550 EKHQLKCLNISDELKVIDV 568
            |.:|.:...:.|:|:.::|
Worm   538 EDYQERRAELWDKLRALNV 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	164/589 (28%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	51/130 (39%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	162/585 (28%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	70/192 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157310
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.840