DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces2c

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_598270.2	Gene:	Ces2c / 171118	RGDID:	621510	Length:	561	Species:	Rattus norvegicus

Alignment Length:	590	Identity:	168/590 - (28%)
Similarity:	249/590 - (42%)	Gaps:	122/590 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 EKTVVSTTY-GPIKGV---KRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQ 90
            |.:.:.||: |.::|.   .|.:..|  ..:|..|||||.|||.||:..|:.||.|:.||..||.
  Rat    31 ESSSIRTTHTGQVRGKLDHVRDTKAG--VHTFLGIPFAKAPVGPLRFAPPEDPEPWSGVRDGTSH 93

  Fly    91 GPKPLQKHFVFE---MTD---------GSEDCLYLNVYT-KNLYPTKPMPVMVWIYGGGFQFGEA 142
            ....||...:.:   :||         .||||||||:|| .:.:....:||||.|:||....|.|
  Rat    94 PAMCLQNIDMLDEVGLTDMKMILSSIPMSEDCLYLNIYTPAHAHEGSNLPVMVCIHGGALVIGMA 158

  Fly   143 SRECYSPDYLLREDVVVISINYRLGPLG---TNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAG 204
            |. |......:.||:||::|.||||.||   |.|:                       ...||.|
  Rat   159 SM-CDGSLLAVNEDLVVVAIQYRLGVLGFFSTGDE-----------------------HARGNWG 199

  Fly   205 LKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWA 269
            ..|||.|||||:.|.:.|||:...:||||.|||..||...:|:..:.||||.||..||..|.|..
  Rat   200 YLDQVAALRWVQQNIAHFGGNPNRVTIFGVSAGGTSVSSHVISPMSQGLFHGAIMESGVALLPDL 264

  Fly   270 VTPQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFGPVIEP 334
            ::...........:.......::..:...|:...|:||      |.|::..|          :.|
  Rat   265 ISETSETVSTTVAKLSGCEATDSETLVRCLRAKSGAEI------LVINKVFK----------MIP 313

  Fly   335 YVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPI---- 395
            .|.....:|:.|.|::.:...:.:|.|||            ..|:..|      |  .:|:
  Rat   314 AVVDGEFLPRHPKELLASEDFHPVPSIIG------------VNTDEYC------C--TIPMVMGT 358

  Fly   396 -----ELNMDRESALCR----------EYGDQLRQCYYGDKTPSLDTLH-EYLQMVSHEYFWFPI 444
                 ||:.:...|:.:          |.||.|.:.|.|: |....||. :|.:|:....|..|
  Rat   359 AQIIKELSRENLQAVLKDTAAQMMLPPECGDLLMEEYMGN-TDDPQTLQIQYAEMMGDFLFVIP- 421

  Fly   445 YRTVLSRLQYARS-APTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNH 508
               .|....:.|| ||.|.|.|.....:|.::|    ...|:.. |.|::.::|.:.......:.
  Rat   422 ---ALQVAHFQRSHAPVYFYEFQHAPSYFKNVR----PPHVKAD-HADEVPFVFGSFFWGIKVDF 478

  Fly   509 TREYKCI-ERLVGLWTHFAACGNPNFDPEQEDLWQPVDPAAVEKHQLKCLNISDELKVIDVPDLK 572
            |.|.|.: .|::..|.:||..||||  .|....|..:|      |..:.|.:..:..|......:
  Rat   479 TEEEKLLSRRMMKYWANFARHGNPN--SEGLPYWPVLD------HDEQYLQLDTQPAVDRALKAR 535

  Fly   573 KLMVW 577
            :|..|
  Rat   536 RLQFW 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	163/563 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	46/125 (37%)
Ces2c	NP_598270.2	COesterase	32..540	CDD:395084	166/587 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810