DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and clt

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster

Alignment Length:	572	Identity:	186/572 - (32%)
Similarity:	292/572 - (51%)	Gaps:	48/572 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 RYRTSEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVR-SCT 88
            |:.:|.|..|....|.:.|.::|.:.|..|.||..:|:|:|||||||:::|:|.|.:.:.. .|:
  Fly    13 RFCSSMKVKVPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCS 77

  Fly    89 SQGPKPLQKH-FVFEMTDGSEDCLYLNVYTKNLYPTK-PMPVMVWIYGGGFQFGEASRECYSPDY 151
            .:|....|:. |..|:. ||||||:||||...:..|: |:||||||:||||.||..:.:.:.|..
  Fly    78 KEGNVSYQRDPFTLEVA-GSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAK 141

  Fly   152 LLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRWVK 216
            |:.::|:|:::|||||.|                  |||.|  ||..:.||.|||||.|||.||:
  Fly   142 LMEQEVIVVTLNYRLGAL------------------GFLSL--PEEGIHGNMGLKDQRLALEWVQ 186

  Fly   217 ANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRNWP---Y 278
            .|.:.|.||..|:|:||:|||.:|||..........||||||..||.....|..  |...|   .
  Fly   187 ENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVF--QNEAPAKTR 249

  Fly   279 RLAVQAG---YAGENNTRDVWEFLKNAKGS-EIIKANG-ELCIDEEKKERIGFSFGPVIEPYVTS 338
            |||...|   :.|:  ::.:..||::.|.: ..|.||. ::...:|::..:.|:|.||:|...:.
  Fly   250 RLAELLGGGDFGGD--SKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSP 312

  Fly   339 HCVVPKKPIEMM-RTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPIELNMDRE 402
            ...:.:..:|:| :.....::|:|:|..|.|||.:..:.|...:...  ||...:||..|.:|.:
  Fly   313 DRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYE--DDLARLVPRNLVLDPQ 375

  Fly   403 SALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQYARSAPTYLYRFDF 467
            :...:|....:|..::..:..|.:.:...:.:.|..:|...:.|.|.........:|.|.||.|:
  Fly   376 APEAQEAASDIRAFFFNGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDY 440

  Fly   468 DSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIERLVGLWTHFAACGNPN 532
            ......:.:|.. .:.:||..|.||:.||| .....:.:.:..:....|||..:|.:||..|.|:
  Fly   441 VGGRNLYKKIFQ-NEDLRGVAHADDICYLF-QMAGDETEMNRDDLMVTERLCEMWANFARDGKPS 503

  Fly   533 FDPEQEDLWQPV-DPAAVEKHQLKCLNISDELKVIDVPDLKKLMVWESFFRR 583
                  .:|:|| .|...|..||.||.|..|||:...||.:::..|.|.:||
  Fly   504 ------PIWKPVKKPHNGEPIQLDCLLIDRELKMCSNPDGERMDFWRSMYRR 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	170/534 (32%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	53/122 (43%)
clt	NP_536784.1	COesterase	22..543	CDD:278561	179/555 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	222	1.000	Domainoid score	I1478
eggNOG	1	0.900	-	-		E2759_KOG1516
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	226	1.000	Inparanoid score	I2231
Isobase	1	0.950	-	0	Normalized mean entropy	S4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm46967
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
	8	7.810