DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ache

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	583	Identity:	173/583 - (29%)
Similarity:	264/583 - (45%)	Gaps:	106/583 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RTSEKTVVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |...:.:|....|.::|::.|: .|....:|..||||:||||..|:..|:|...|:.|...|:
Mouse    34 REDPQLLVRVRGGQLRGIRLKA-PGGPVSAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATT-- 95

  Fly    92 PKPLQK---HFV------FEMTDG-------SEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFG 140
               .|.   .:|      ||.|:.       |||||||||:|....|..|.||::|||||||..|
Mouse    96 ---FQNVCYQYVDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSG 157

  Fly   141 EASRECYSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAG 204
            .||.:.|...:|.: |..|::|:|||:|..|.            ::|||       ..:.|||.|
Mouse   158 AASLDVYDGRFLAQVEGAVLVSMNYRVGTFGF------------LALPG-------SREAPGNVG 203

  Fly   205 LKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWA 269
            |.||.|||:||:.|.:.||||..::|:||:|||:|||...:::..:..|||:|:..||....|||
Mouse   204 LLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWA 268

  Fly   270 VTPQRNWPYRLAVQA-------GYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEE-----KKE 322
            .........|..:.|       |.||.|:| ::...|:.....::        :|.|     ::.
Mouse   269 TVSAGEARRRATLLARLVGCPPGGAGGNDT-ELIACLRTRPAQDL--------VDHEWHVLPQES 324

  Fly   323 RIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEG--LLLYSE---TKTNPKC 382
            ...|||.||::....|     ..|..::.|....::.:::|.|.:||  .|:|..   :|.|...
Mouse   325 IFRFSFVPVVDGDFLS-----DTPEALINTGDFQDLQVLVGVVKDEGSYFLVYGVPGFSKDNESL 384

  Fly   383 LNELDDCRFVVPIELNMDRESALCRE-----YGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWF 442
            ::.   .:|:..:.:.:.:.|.|..|     |.|.|   :..|.|...|.:.   .:|.......
Mouse   385 ISR---AQFLAGVRIGVPQASDLAAEAVVLHYTDWL---HPEDPTHLRDAMS---AVVGDHNVVC 440

  Fly   443 PIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKN 507
            |:.: :..||. |:.|..|.|.|:       |...........|..||.::.::|...|...|..
Mouse   441 PVAQ-LAGRLA-AQGARVYAYIFE-------HRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNY 496

  Fly   508 HTREYKCIERLVGLWTHFAACGNPNFDP--EQEDLWQPVDPAAVEKHQLKCLNISDELKVIDV 568
            .|.|....:||:..||:||..|:|| ||  .:...|.|...||   .|...||    ||.::|
Mouse   497 TTEERIFAQRLMKYWTNFARTGDPN-DPRDSKSPQWPPYTTAA---QQYVSLN----LKPLEV 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	167/562 (30%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	50/122 (41%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	172/580 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832862
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840