DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces1d

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_579829.3	Gene:	Ces1d / 113902	RGDID:	70896	Length:	565	Species:	Rattus norvegicus

Alignment Length:	576	Identity:	166/576 - (28%)
Similarity:	241/576 - (41%)	Gaps:	160/576 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYG--QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |...||:|..|.:.| |..::.|  |....|..|||||||:|.||:..|||.|.|..|::.||..
  Rat    21 SSPPVVNTVKGKVLG-KYVNLEGFAQPVAVFLGIPFAKPPLGSLRFAPPQPAEPWNFVKNTTSYP 84

  Fly    92 PK----------------------PLQKHFVFEMTDGSEDCLYLNVYT-KNLYPTKPMPVMVWIY 133
            |.                      |||         .||||||||||| .:|.....:||||||:
  Rat    85 PMCSQDAVGGQVLSELFTNRKENIPLQ---------FSEDCLYLNVYTPADLTKNSRLPVMVWIH 140

  Fly   134 GGGFQFGEASRECYSPDYL-LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPEL 197
            |||...|.||  .|....| ..|:|||::|.||||       .|           ||....|...
  Rat   141 GGGLVVGGAS--TYDGQVLSAHENVVVVTIQYRLG-------IW-----------GFFSTGDEHS 185

  Fly   198 DVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSG 262
            .  ||.|..|||.||.||:.|.:.|||:..::||||:|||..||..::::.....|||:||..||
  Rat   186 Q--GNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGFSVSALVLSPLAKNLFHRAISESG 248

  Fly   263 NTLSPWAVT----PQRNWPYRLAVQAG----------YAGENNTRDVWEFLKNAKGSEIIKANGE 313
            ..|:...:|    |..|   .:|..:|          :.....|.|  |.|:.:....:.|
  Rat   249 VVLTSALITTDSKPIAN---LIATLSGCKTTTSAVMVHCLRQKTED--ELLETSLKLNLFK---- 304

  Fly   314 LCIDEEKKERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKT 378
            |.:....||...|.      |.|....|:||.|.|::.....|.:|.|:|
  Rat   305 LDLLGNPKESYPFL------PTVIDGVVLPKTPEEILTEKSFNTVPYIVG--------------- 348

  Fly   379 NPKCLNELDDCRFVVPI-------ELNMDRESA---LCREYGDQLRQCYYGDKTPSLDTLHEYLQ 433
                :|: .:..:::|.       |..:|:::|   |.:.|             |:|....:.:.
  Rat   349 ----INK-QEFGWIIPTLMGYPLSEGKLDQKTAKSLLWKSY-------------PTLKISEKMIP 395

  Fly   434 MVSHEYF--------------------WFPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRIL 478
            :|:.:||                    .|.:...::||......|||::|.|::.....:.:|
  Rat   396 VVAEKYFGGTDDPAKRKDLFQDLVADVMFGVPSVMVSRSHRDAGAPTFMYEFEYRPSFVSAMR-- 458

  Fly   479 SCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKC-IERLV-GLWTHFAACGNPN 532
              .|.|.|. |||:|..:|.:..   ||:...|.:. :.::| ..|.:||..|:||
  Rat   459 --PKTVIGD-HGDELFSVFGSPF---LKDGASEEETNLSKMVMKYWANFARNGSPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	165/572 (29%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	50/123 (41%)
Ces1d	NP_579829.3	COesterase	24..545	CDD:278561	165/573 (29%)
		Aes	<121..>239	CDD:223730	54/139 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336164
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.840