Protein Alignment alpha-Est9 and CEL

DIOPT Version :10

• Sequence 1: NP_731165.2
• Gene: alpha-Est9 / 40897
• FlyBaseID: FBgn0015577
• Length: 587
• Species: Drosophila melanogaster
• Sequence 2: NP_001798.3
• Gene: CEL / 1056
• HGNCID: 1848
• Length: 753
• Species: Homo sapiens
• Alignment Length: 547
• Identity: 158/547 - (28%)
• Similarity: 232/547 - (42%)
• Gaps: 99/547 - (18%)

  Fly    34 VSTTYGPIKGVKRK-SIYGQSYFSFERIPFAKPPVGELRYKA---PQPPEVWTEVRSCTSQGPKP 94
            |.|..|.::||.:| .:.|.|...|:.||||.|.      ||   |||...|.......:...:.
Human    26 VYTEGGFVEGVNKKLGLLGDSVDIFKGIPFAAPT------KALENPQPHPGWQGTLKAKNFKKRC 84

  Fly    95 LQKHFVFEMTDGSEDCLYLNVYT----KNLYPTKPMPVMVWIYGGGFQFGEASRECYSPDYL--- 152
            ||.....:.|.|.|||||||::.    |.:  ::.:|||:|||||.|..|......:..:||
Human    85 LQATITQDSTYGDEDCLYLNIWVPQGRKQV--SRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDG 147

  Fly   153 ----LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALR 213
                .|.:|:|::.|||:|||                  |||...|..|  |||.||:||.:|:.
Human   148 EEIATRGNVIVVTFNYRVGPL------------------GFLSTGDANL--PGNYGLRDQHMAIA 192

  Fly   214 WVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQRN--- 275
            |||.|.:.||||..|||:||:|||.|||....::....||..:||..||..||||.:  |:|
Human   193 WVKRNIAAFGGDPNNITLFGESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVI--QKNPLF 255

  Fly   276 WPYRLAVQAGY-AGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIG---------FSFGP 330
            |..::|.:.|. .|:           .|:.::.:|......:....|..:.         ..|.|
Human   256 WAKKVAEKVGCPVGD-----------AARMAQCLKVTDPRALTLAYKVPLAGLEYPMLHYVGFVP 309

  Fly   331 VIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYS-----ETKTNPKCLNELDDCR 390
            ||:     ...:|..||.:...|  .:|..|.|..:.:|.:..|     ..|.|.| :.|.|..:
Human   310 VID-----GDFIPADPINLYANA--ADIDYIAGTNNMDGHIFASIDMPAINKGNKK-VTEEDFYK 366

  Fly   391 FVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHE---YFWFPIYRTVLSRL 452
            .|....:......|  :...|...:.:..|  ||.:  ::...:|..|   .|..|....:....
Human   367 LVSEFTITKGLRGA--KTTFDVYTESWAQD--PSQE--NKKKTVVDFETDVLFLVPTEIALAQHR 425

  Fly   453 QYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCIER 517
            ..|:||.||.|.|...|:       :....|..|..|.||:.|:|....|.......::....:.
Human   426 ANAKSAKTYAYLFSHPSR-------MPVYPKWVGADHADDIQYVFGKPFATPTGYRPQDRTVSKA 483

  Fly   518 LVGLWTHFAACGNPNF-DPEQEDLWQP 543
            ::..||:||..|:||. |......|:|
Human   484 MIAYWTNFAKTGDPNMGDSAVPTHWEP 510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	32..577	CDD:395084	158/547 (29%)
CEL	NP_001798.3	Heparin-binding	21..121		33/102 (32%)
		COesterase	26..542	CDD:395084	158/547 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
		Mucin-like	584..677	CDD:464997
		Mucin-like	639..731	CDD:464997