DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and Ces1d

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_444430.2	Gene:	Ces1d / 104158	MGIID:	2148202	Length:	565	Species:	Mus musculus

Alignment Length:	567	Identity:	159/567 - (28%)
Similarity:	235/567 - (41%)	Gaps:	142/567 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEKTVVSTTYGPIKGVKRKSIYG--QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQG 91
            |...||:|..|.:.| |..::.|  |....|..:||||||:|.||:..|||.|.|:.|::.||..
Mouse    21 SSPPVVNTVKGKVLG-KYVNLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYP 84

  Fly    92 PK----------------------PLQKHFVFEMTDGSEDCLYLNVYT-KNLYPTKPMPVMVWIY 133
            |.                      |||         .||||||||:|| .:|.....:||||||:
Mouse    85 PMCSQDAVGGQVLSELFTNRKENIPLQ---------FSEDCLYLNIYTPADLTKNSRLPVMVWIH 140

  Fly   134 GGGFQFGEASRECYSPDYL---LREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDP 195
            |||...|.||    :.|.|   ..|:|||::|.||||       .|           ||....|.
Mouse   141 GGGLVVGGAS----TYDGLALSAHENVVVVTIQYRLG-------IW-----------GFFSTGDE 183

  Fly   196 ELDVPGNAGLKDQVLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICM 260
            .  ..||.|..|||.|||||:.|.:.|||:..::||||:|||..||..::::.....|||:||..
Mouse   184 H--SRGNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVLSPLAKNLFHRAISE 246

  Fly   261 SGNTLSPWAVTPQRNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDE-----EK 320
            ||.:|:...:|........|...........:..:...|:.....|:::.:.:|.:.:     ..
Mouse   247 SGVSLTAALITTDVKPIAGLVATLSGCKTTTSAVMVHCLRQKTEDELLETSLKLNLFKLDLLGNP 311

  Fly   321 KERIGFSFGPVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNE-GLLL-------YSETK 377
            ||...|.      |.|....|:||.|.|::.....:.:|.|:|....| |.::       .:|.|
Mouse   312 KESYPFL------PTVIDGVVLPKAPEEILAEKSFSTVPYIVGINKQEFGWIIPTLMGYPLAEGK 370

  Fly   378 TNPKCLNELDDCRFVVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFW- 441
            .:.|..|.|                  |.:.|             |:|......:.:|:.:|..
Mouse   371 LDQKTANSL------------------LWKSY-------------PTLKISENMIPVVAEKYLGG 404

  Fly   442 -------------------FPIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKVRGT 487
                               |.:...::||......|.||:|.|::.....:.:|    .|.|.|.
Mouse   405 TDDLTKKKDLFQDLMADVVFGVPSVIVSRSHRDAGASTYMYEFEYRPSFVSAMR----PKAVIGD 465

  Fly   488 CHGDDLSYLFYNSLARKLKNHTREYKC-IERLV-GLWTHFAACGNPN 532
             |||::..:|.:..   ||:...|.:. :.::| ..|.:||..||||
Mouse   466 -HGDEIFSVFGSPF---LKDGASEEETNLSKMVMKFWANFARNGNPN 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	158/563 (28%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	50/125 (40%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	158/564 (28%)
		Aes	<121..>239	CDD:223730	54/141 (38%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.740