DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est9 and Ces2a

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	NP_598721.1	Gene:	Ces2a / 102022	MGIID:	2142491	Length:	558	Species:	Mus musculus

Alignment Length:	591	Identity:	173/591 - (29%)
Similarity:	251/591 - (42%)	Gaps:	138/591 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 PIKGVKRKSIYG---------QSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPL 95
            ||:...|..:.|         ....:|..|||||||||.||:..|:.||.|:.||..|||....|
Mouse    32 PIRNTHRGQVRGSFVHVKDTKSGVHAFLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCL 96

  Fly    96 QKHFVFEMTDG------------SEDCLYLNVYTKNLYPT-----KPMPVMVWIYGGGFQFGEAS 143
            |.. :..:.|.            ||||||||:||    ||     ..:||||||:|||...|.||
Mouse    97 QPD-IMNLEDAKEMNLILPPISMSEDCLYLNIYT----PTHAQEGSNLPVMVWIHGGGLVVGSAS 156

  Fly   144 RECYSPDYLLREDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQ 208
            ....| .....|::|:::|.||||.|                  ||....|..  ..||.|..||
Mouse   157 MNDVS-KLAATEEIVIVAIQYRLGVL------------------GFFSTGDQH--ARGNWGYLDQ 200

  Fly   209 VLALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWAVTPQ 273
            |.|||||:.|.:.|||:...:||||.|||..||...:::..:.||||.||..||..|.|..::
Mouse   201 VAALRWVQKNIAYFGGNRDRVTIFGVSAGGTSVSSHILSPMSKGLFHGAIMQSGVALLPDLIS-- 263

  Fly   274 RNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGEL-CIDEEKKERIGFSFGPVIE--PY 335
                            :.:..|::.:.|..|.|...:...: |:..:.|:.| .:...|.:  |.
Mouse   264 ----------------DTSEVVYKTVANLSGCEATDSEALIHCLRAKSKQEI-LAINQVFKMIPA 311

  Fly   336 VTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVPIELNMD 400
            |.....:||.|.|::.:...:.:|.|||                   :| .|:|.:.||:.:.:|
Mouse   312 VVDGEFLPKHPQELLTSMDFHPVPSIIG-------------------VN-TDECGWGVPMFMGLD 356

  Fly   401 -------RES------------ALCREYGDQLRQCYYGDKTPSLDTLH-EYLQMVSHEYFWFPIY 445
                   ||:            .|..|....|.:.|.|| |...:||. ::.:|:....|..|
Mouse   357 HIIKNITRETLPAVLKNTAARMMLPPECSHLLVEEYMGD-TEDPETLQAQFREMLGDFMFVIP-- 418

  Fly   446 RTVLSRLQYARS-APTYLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHT 509
              .|....:.|| ||.|.|.|...|....|:|    ...|:.. ||||::::|.:.|.....:.|
Mouse   419 --ALQVAHFQRSQAPVYFYEFQHLSSFIKHVR----PSHVKAD-HGDDVAFVFGSYLWDMNLDLT 476

  Fly   510 REYKCIER-LVGLWTHFAACGNPNFDPEQEDL--WQPVDPAAVEKHQLKCLNISDELKVIDVPDL 571
            .|.:.::| ::..|.:||..||||    .|.|  |..:|      |..:.|.:..:..|......
Mouse   477 EEEELLKRMMMKYWANFARNGNPN----SEGLPSWPVLD------HDEQYLQLDTQPAVGRALKA 531

  Fly   572 KKLMVW 577
            ::|..|
Mouse   532 RRLQFW 537

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	169/567 (30%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	48/126 (38%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	172/589 (29%)
Ces2a	NP_598721.1	Aes	<127..>230	CDD:223730	49/127 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832758
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D222591at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.750