DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est9 and ache

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_002940088.1	Gene:	ache / 100490673	XenbaseID:	XB-GENE-923160	Length:	600	Species:	Xenopus tropicalis

Alignment Length:	588	Identity:	175/588 - (29%)
Similarity:	259/588 - (44%)	Gaps:	105/588 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 VVSTTYGPIKGVKRKSIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVRSCTSQGPKPLQK 97
            :|||..|.::|: |:.:......:|..||||:|||.::|::..:|.:.||:|...|:. |....:
Frog    30 LVSTRSGKVRGL-RQPVLSTHVSAFLGIPFAEPPVDKMRFRRSEPKKPWTDVWDATAY-PNACYQ 92

  Fly    98 HF--------VFEMTDG----SEDCLYLNVYTKNLYPTKPMPVMVWIYGGGFQFGEASRECYSPD 150
            :|        ..||.:.    ||||||||::..:..|:. ..||||||||||..|.:|.:.|...
Frog    93 YFDTLYPGFPGMEMWNPNRPMSEDCLYLNIWVPHPRPSN-ATVMVWIYGGGFYSGSSSLDVYDGR 156

  Fly   151 YLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQVLALRW 214
            ||.. |:|:|:|:|||:|..                  |||.|....:|.|||.||.||.|||:|
Frog   157 YLCHAENVIVVSMNYRVGAF------------------GFLTLTPGSVDAPGNVGLFDQRLALQW 203

  Fly   215 VKANCSRFGGDSANITIFGDSAGSASVHYMMITEQTHGLFHKAICMSGNTLSPWA-VTPQRNWPY 278
            |:.|.:.||||...:||||:|||:.||...:::..:|.||.||...||:..:||| :|||.
Frog   204 VQDNIAFFGGDPRTVTIFGESAGAVSVGMHVLSPGSHHLFSKAALQSGSPNTPWATITPQE---- 264

  Fly   279 RLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCID-EEKKERIGFSFGPVIEPYVTSHCVV 342
                     ....|..:.:||....|::....|   |:. ::.:|.|...|..:..|.|.....|
Frog   265 ---------ARRRTELLGKFLDCRMGNDTELLN---CLRVKQPQELIDHEFSVLPAPSVFRFAFV 317

  Fly   343 --------PKKPIEMMRTAWSNNIPLIIGGVSNEG--LLLYSE---TKTNPKCLNE---LDDCRF 391
                    |:.|..:|........|||:|...|||  .|||..   :|.|...:..   |...:.
Frog   318 PVPDADFFPEPPEILMNMGRFKPCPLIMGVNQNEGSYFLLYGAPGFSKNNESLITREEFLGGVKM 382

  Fly   392 VVPIELNMDRESALCREYGDQLRQCYYGDKTPSLDTLHEYLQMVSHEYFWFPIYRTVLSRLQY-- 454
            .|| :.|.....|:..:|.|      :.|:...:.......|:|..        ..|:..|.|
Frog   383 SVP-QANDIALEAVVMQYTD------WADEHAGVKNREAMDQLVGD--------HNVICPLTYFA 432

  Fly   455 ARSAPT----YLYRFDFDSKHFNHLRILSCGKKVRGTCHGDDLSYLFYNSLARKLKNHTREYKCI 515
            .:.|.|    |.|.||..:.:.       ...:..|..||.::.::|...|...|....:|....
Frog   433 GKVAETGNRVYTYFFDHRASNL-------AWPQWMGVPHGYEIEFVFGLPLDANLNYTPQEEALS 490

  Fly   516 ERLVGLWTHFAACGNPNFDPEQEDLWQPVDP--AAVEKHQLKCLNIS-DELKVIDVPDLKKLMVW 577
            .|::..|.:||..|:||   |..|..||..|  .|.|:..:...|.. .||:.|.|   :..|.|
Frog   491 RRMMRYWANFARTGDPN---EGNDAHQPRWPLYTASEQRYMALNNKPYQELQGIRV---QTCMFW 549

  Fly   578 ESF 580
            ..|
Frog   550 NRF 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	167/560 (30%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	51/122 (42%)
ache	XP_002940088.1	COesterase	31..549	CDD:395084	173/582 (30%)
ache	XP_002940088.1	AChE_tetra	564..597	CDD:400834
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910