DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est9 and nlgn1

DIOPT Version :9

Sequence 1:	NP_731165.2	Gene:	alpha-Est9 / 40897	FlyBaseID:	FBgn0015577	Length:	587	Species:	Drosophila melanogaster
Sequence 2:	XP_017213657.1	Gene:	nlgn1 / 100002610	ZFINID:	ZDB-GENE-090918-1	Length:	867	Species:	Danio rerio

Alignment Length:	686	Identity:	173/686 - (25%)
Similarity:	263/686 - (38%)	Gaps:	234/686 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SEK-----TVVSTTYGPIKGVKRK---SIYGQSYFSFERIPFAKPPVGELRYKAPQPPEVWTEVR 85
            |||     .:|:||||.::|.|::   .|.| ....|..:|:|.||.||.|::.|:||..|:|:|
Zfish    46 SEKLDETDPIVTTTYGKVRGFKKELNNEILG-PVIQFLGVPYAAPPTGERRFQPPEPPISWSEIR 109

  Fly    86 SCTSQGPKPLQKHFVFE----------------------MTDGSEDCLYLNVYTKNLYPTK---- 124
            :.|...|...|.  :.|                      :.|.|||||:||:|.    ||:
Zfish   110 NATQFAPVCPQT--LLEGRLPDVMLPVWFTNSIEVVSSYVQDQSEDCLFLNIYV----PTEDVKR 168

  Fly   125 --------------------------------------------PMPVMVWIYGGGFQFGEASRE 145
                                                        |.||||:::||.:.  |.:..
Zfish   169 ISKECARKPGKKICRKGGPLSKKQNDDLADNDGAEDEDIRESGSPKPVMVFVHGGSYM--EGTGN 231

  Fly   146 CYSPDYLLR-EDVVVISINYRLGPLGTNDDTWKKKHIFNISLPGFLCLDDPELDVPGNAGLKDQV 209
            .:....|.. .:|:||::|||||.|                  |||...|..  ..||.||.|.:
Zfish   232 MFDGSILASYGNVIVITVNYRLGVL------------------GFLSTGDQA--AKGNYGLLDLI 276

  Fly   210 LALRWVKANCSRFGGDSANITIFGDSAGSASVHYMMI---------TEQTHGLFHKAICMSGNTL 265
            .||||...|.:.||||...||:||..||::.|:.:.:         :..|.|||.:||..||..|
Zfish   277 QALRWTSENIAFFGGDPLRITVFGSGAGASCVNLLTLSHYSEGNRWSNSTKGLFQRAIAQSGTAL 341

  Fly   266 SPWAVTPQ-RNWPYRLAVQAGYAGENNTRDVWEFLKNAKGSEIIKANGELCIDEEKKERIGFSFG 329
            |.|||:.| ..:...||.:.|.    |.:|..|.::..:.    |...||...:.:..|...:||
Zfish   342 SSWAVSFQPAKYARMLAKKVGC----NLKDTVEMVECLQK----KHYKELVEQDIQPARYHIAFG 398

  Fly   330 PVIEPYVTSHCVVPKKPIEMMRTAWSNNIPLIIGGVSNEGLLLYSETKTNPKCLNELDDCRFVVP 394
            |||:     ..|:|..|..:|......|..:::|....|||                   :||
Zfish   399 PVID-----GDVIPDDPQILMEQGEFLNYDIMLGVNQGEGL-------------------KFV-- 437

  Fly   395 IELNMDRESALCRE-------------YG-----DQLRQC---YYGD----KTPSLDTLHEYLQM 434
             ||.:|.|:.:...             ||     |.||:.   .|.|    ..|  :|..:.|..
Zfish   438 -ELIVDNENGVQANDFDYAVSSFVDDLYGYPEGKDILRETIKFMYTDWADRHNP--ETRRKTLLA 499

  Fly   435 VSHEYFWF-PIYRTVLSRLQYARSAPTYLYRFDFDSKHFNHLRILSCGKKV---RGTCHGDDLSY 495
            :..::.|. |...|  :.|..:..:|||.|.|      ::|.:.    ::|   ....|||::.|
Zfish   500 LFTDHQWVAPAVAT--ADLHSSFGSPTYFYAF------YHHCQT----EQVPPWADAAHGDEIPY 552

  Fly   496 LFYNSLARKLKNHTREYKC--------IERLV-GLWTHFAACGNPNFDPEQEDLWQPVDPAAVEK 551
            :|    ...:...|..:.|        :..:| ..||:||..|:||         |||
Zfish   553 VF----GLPMIGPTELFPCNFSKNDVMLSAVVMTYWTNFAKTGDPN---------QPV------- 597

  Fly   552 HQLKCLNISDELKVIDV-PDLKKLMVWESFFRRDEL 586
                    ..:.|.|.. |:..:.:.|..:.::|:|
Zfish   598 --------PQDTKFIHTKPNRFEEVAWTRYNQKDQL 625

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est9	NP_731165.2	COesterase	33..555	CDD:278561	164/643 (26%)
alpha-Est9	NP_731165.2	Aes	<115..>237	CDD:223730	43/170 (25%)
nlgn1	XP_017213657.1	COesterase	53..647	CDD:306613	170/679 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740