Protein Alignment alpha-Est10 and CES2

DIOPT Version :9

• Sequence 1: NP_001246962.1
• Gene: alpha-Est10 / 40896
• FlyBaseID: FBgn0015569
• Length: 581
• Species: Drosophila melanogaster
• Sequence 2: NP_001352334.1
• Gene: CES2 / 8824
• HGNCID: 1864
• Length: 559
• Species: Homo sapiens
• Alignment Length: 527
• Identity: 163/527 - (30%)
• Similarity: 237/527 - (44%)
• Gaps: 63/527 - (11%)

  Fly    73 SFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQT------------HMFFRKYAGSE 125
            :|..|||||||:|.|||..||..|.|....|.|:.....||.            :|.|...:.||
Human    57 TFLGIPFAKPPLGPLRFAPPEPPESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDSMSE 121

  Fly   126 DCLYLNVYVKDLQPDKLR-PVMVWIYGGGYQVGEASRDMYSPDFFMS-KDVVIVTVAYRLGALGF 188
            |||||::|......:... ||||||:||....|.||  :|......: ::||:|.:.||||.|||
Human   122 DCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMAS--LYDGSMLAALENVVVVIIQYRLGVLGF 184

  Fly   189 LSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGGASTHFLALSPQTEGLI 253
            .|..|.  :..||.|..||:.|||||||||..|||:.:.:|:|||||||.|...|.:||.::||.
Human   185 FSTGDK--HATGNWGYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVSSLVVSPISQGLF 247

  Fly   254 HKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVKATATVLSNDE 318
            |.||:.||..|.|.......:....:...|........:|:...||..|..||:..        .
Human   248 HGAIMESGVALLPGLIASSADVISTVVANLSACDQVDSEALVGCLRGKSKEEILAI--------N 304

  Fly   319 KHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRPATLD 383
            |..:::        |...:...:.:.|.||:.::....:|.:.|..:.|.....|:|.|...|..
Human   305 KPFKMI--------PGVVDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPKVMRIYDTQK 361

  Fly   384 EVGN--CKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRA 446
            |:..  .:..|...|.|.:.|   ..:|..|::.|.||....|....:|.|:.:...|..|..:.
Human   362 EMDREASQAALQKMLTLLMLP---PTFGDLLREEYIGDNGDPQTLQAQFQEMMADSMFVIPALQV 423

  Fly   447 ALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHK 511
            |  ..:.|.||.|.|.|.|.......||    ...|: ..|||:|.::|.|.........:.|.:
Human   424 A--HFQCSRAPVYFYEFQHQPSWLKNIR----PPHMK-ADHGDELPFVFRSFFGGNYIKFTEEEE 481

  Fly   512 VIT-GMVDVWTSFAAHGDPNCESIKSLKFAPI-ENVTNFKCLNIGD-----------QFEVMALP 563
            .:: .|:..|.:||.:|:||.|   .|...|: :....:..||:..           ||...|||
Human   482 QLSRKMMKYWANFARNGNPNGE---GLPHWPLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALP 543

  Fly   564 E-LQKIE 569
            : :|::|
Human   544 QKIQELE 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	153/485 (32%)
		Aes	<132..>279	CDD:223730	63/148 (43%)
CES2	NP_001352334.1	COesterase	30..538	CDD:306613	157/513 (31%)
		Prevents secretion from ER. /evidence=ECO:0000255	556..559

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142696
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.790