DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and TG

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_003226.4	Gene:	TG / 7038	HGNCID:	11764	Length:	2768	Species:	Homo sapiens

Alignment Length:	660	Identity:	142/660 - (21%)
Similarity:	238/660 - (36%)	Gaps:	209/660 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 RRYWVSLLRHFSLIPNKSVPKVFTNGDFIQQVISFKYEQRKLSTAIYSVIKTKSGPVRGVKRNTI 66
            |:..:|||.:.:.:|  ||| :.|:|..:                         |..:.::..|.
Human  2185 RKPGISLLSYEASVP--SVP-ISTHGRLL-------------------------GRSQAIQVGTS 2221

  Fly    67 WGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQTHMFFRKYAG-SEDCLYL 130
            | .....|..:|:|.||:.:.||:|||.:. |....|.:.|.....|.........| |||||||
Human  2222 W-KQVDQFLGVPYAAPPLAERRFQAPEPLN-WTGSWDASKPRASCWQPGTRTSTSPGVSEDCLYL 2284

  Fly   131 NVYVKDLQPDKLRP---VMVWIY-------GGGYQVGEASRDMYSPDFFMSK--DVVIVTVAYRL 183
            ||::    |..:.|   |:|:.:       ..|:...:.|        |::.  ::::||.:||:
Human  2285 NVFI----PQNVAPNASVLVFFHNTMDREESEGWPAIDGS--------FLAAVGNLIVVTASYRV 2337

  Fly   184 GALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFGESAGG--ASTHFLALS 246
            |..||||....:  |.||.||.||:.||.|||.:|..||||...::|..:..|.  ||.|.|...
Human  2338 GVFGFLSSGSGE--VSGNWGLLDQVAALTWVQTHIRGFGGDPRRVSLAADRGGADVASIHLLTAR 2400

  Fly   247 PQTEGLIHKAIVMSGSVLCP---WTQPPRNNWAYRLAQKLGYTGDNKDKAIFEFLRSMSGGEIVK 308
            .....|..:|::|.||.|.|   .:.......|..||:::.....:..:.: ..||......:..
Human  2401 ATNSQLFRRAVLMGGSALSPAAVISHERAQQQAIALAKEVSCPMSSSQEVV-SCLRQKPANVLND 2464

  Fly   309 ATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYP 373
            |...:|:.....|    .:|||::.:     .:.:.|...::.|....:.::.|.:..:||
Human  2465 AQTKLLAVSGPFH----YWGPVIDGH-----FLREPPARALKRSLWVEVDLLIGSSQDDGL---- 2516

  Fly   374 EVSRRPATLDEVGNCKNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYRE 438
             ::|..|.                    .:..|:.|....|..|
Human  2517 -INRAKAV--------------------KQFEESRGRTSSKTAF--------------------- 2539

  Fly   439 FWHPIYRAALNRV-------RQSSAPTYLYRFDHDS--------KLCNAIR--IVLC-------- 478
                 |:|..|.:       |..:|.|:.|..:|.:        .|.||.|  .::|
Human  2540 -----YQALQNSLGGEDSDARVEAAATWYYSLEHSTDDYASFSRALENATRDYFIICPIIDMASA 2599

  Fly   479 -GHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDV----------------------- 519
             ..:.||      ..:::|       ||::..|..:..:.||
Human  2600 WAKRARG------NVFMYH-------APENYGHGSLELLADVQFALGLPFYPAYEGQFSLEEKSL 2651

  Fly   520 -------WTSFAAHGDPNCESIKSLK----------FAPIENVTNFKCLNIGDQFEVMALPELQK 567
                   ::.|...|:||.....|.|          |.|.....|:|      :|..: ||..|.
Human  2652 SLKIMQYFSHFIRSGNPNYPYEFSRKVPTFATPWPDFVPRAGGENYK------EFSEL-LPNRQG 2709

  Fly   568 IEPVWNSFYA 577
            ::....||::
Human  2710 LKKADCSFWS 2719

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	123/576 (21%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	48/163 (29%)
TG	NP_003226.4	TY	33..92	CDD:238114
		TY	95..160	CDD:238114
		TY	300..358	CDD:238114
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	521..545
		Thyroglobulin_1	599..658	CDD:395039
		Thyroglobulin_1	662..724	CDD:395039
		TY	729..>776	CDD:412186
		TY	<892..922	CDD:412186
		TY	1004..1073	CDD:238114
		TY	1077..1145	CDD:238114
		TY	1149..1210	CDD:238114
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1456..1469
		Ephrin_rec_like	1465..1510	CDD:400166
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1470..1486
		Type II. /evidence=ECO:0000269\|PubMed:8797845	1487..1503
		TY	1520..1567	CDD:214561
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1603..1723
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1724..1892
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	1893..1995
		Type IIIB. /evidence=ECO:0000269\|PubMed:8797845	1996..2129
		Type IIIA. /evidence=ECO:0000269\|PubMed:8797845	2130..2187		1/1 (100%)
		Cholinesterase-like (ChEL). /evidence=ECO:0000250\|UniProtKB:O08710	2188..2768		141/657 (21%)
		COesterase	2197..2718	CDD:395084	137/645 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2727..2768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142809
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930