DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment alpha-Est10 and LOC688542

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	XP_038954018.1	Gene:	LOC688542 / 688542	RGDID:	1587637	Length:	559	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	169/506 - (33%)
Similarity:	235/506 - (46%)	Gaps:	60/506 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 TKSGPVRG----VKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQ 113
            |.:|.|||    ||...|   ...:|..|||||||||.|||..|||.|||....|.||.....||
  Rat    36 THTGQVRGSLVHVKDTDI---DVHTFLGIPFAKPPVGPLRFAPPEAPEPWSGVRDATSHPAMCLQ 97

  Fly   114 T------------HMFFRKYAGSEDCLYLNVYVKDLQPDKLR-----PVMVWIYGGGYQVGEASR 161
            .            .:.....:.||||||||:|.    |....     ||||||:||...||.||
  Rat    98 NDNMMGSEDMKIMKLILPPISMSEDCLYLNIYA----PTHAHEGSNLPVMVWIHGGALTVGMAS- 157

  Fly   162 DMYSPDFF-MSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDS 225
             ||..... .::|||:||:.||||.|||.|..|.  :..||.|..||:.|||||||||..|||:.
  Rat   158 -MYDGSMLAATEDVVVVTIQYRLGVLGFFSTGDE--HARGNWGYLDQVAALRWVQQNIAHFGGNP 219

  Fly   226 NNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLGYTGDNK 290
            |.:|:|||||||.|.....:||.::||.|.||:.||.|:.|......:...||:...|.......
  Rat   220 NRVTIFGESAGGTSVSSHVVSPMSQGLFHGAIMESGVVVLPDLISRSSEMVYRIVANLSGCAAVD 284

  Fly   291 DKAIFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVEPYTTEHTVVAKQPHELMQNSWSH 355
            .:.:.:.||..|..||:        :..|..:|:        |...:...:.|.|.||:.::..|
  Rat   285 SETLMQCLRGKSEAEIL--------DINKVFKII--------PAVVDGEFLPKHPQELLASANFH 333

  Fly   356 RIPMMFGGTSFEGLLFYPEVSRRPATLDEVGNCKNLLPSDL-GLNLDPKLRENYGLQLKKAYFGD 419
            |:|.:.|..:.|.....|.:......::|:  .:..||:.| ...|...|....|..|.:.|.||
  Rat   334 RVPSIIGINNDEYGWILPMIFDSAQKIEEI--TRKTLPTVLKSTALKMMLPPECGDLLMEEYMGD 396

  Fly   420 EPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLYRFDHDSKLCNAIRIVLCGHQMRG 484
            ....:....:|.|:.....|..|..:.|  ..::|.||.|.|.|.|.|..   .:.|...|....
  Rat   397 TEDPKTLQAQFREMMGDFMFVIPALQVA--HFQRSHAPVYFYEFQHRSSF---FKDVKPPHVKAD 456

  Fly   485 VCHGDDLCYIFHSMLSHQSAPDSPEHKVIT-GMVDVWTSFAAHGDPNCESI 534
              |||::..:|..::.....|.:.|.:::: .::..|.:||.||:||.|.:
  Rat   457 --HGDEVFLVFGYLVGDIKFPHTEEEELLSRKIMKYWANFARHGNPNSEGL 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	169/506 (33%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	69/152 (45%)
LOC688542	XP_038954018.1	COesterase	30..538	CDD:395084	169/506 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.910