DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Ces1a

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_001177304.1	Gene:	Ces1a / 679817	RGDID:	1583671	Length:	563	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	161/530 - (30%)
Similarity:	222/530 - (41%)	Gaps:	87/530 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFE----------KIPFAKPPVGDLRFKAPEAVEPWDQELDC 104
            |:.|..|.|.         |.|.|.|          .:||||||:|.|||..|:..|.|....:.
  Rat    25 VVDTLQGKVL---------GKYISLEGFTQPVAVFLGVPFAKPPLGSLRFAPPQPAESWSFVKNA 80

  Fly   105 TS--------PADKPLQTHMFFRKYAG-----SEDCLYLNVY-VKDLQPDKLRPVMVWIYGGGYQ 155
            ||        ....|:.:.:|..:...     ||||||||:| ..||......|||||::|||..
  Rat    81 TSYPPMCSQITGVGPVLSEVFTNQLENVPLEYSEDCLYLNIYSPTDLTSKDRLPVMVWVHGGGLL 145

  Fly   156 VGEASR-DMYSPDFFMSKDVVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIE 219
            .|.||. |..:  ....:.||:|.:.||||..||||..|....  ||.|..||:.||:|||.||.
  Rat   146 SGGASTFDGLA--LSTHEKVVVVVIQYRLGIWGFLSTGDEHSR--GNWGHFDQVAALQWVQNNIV 206

  Fly   220 AFGGDSNNITLFGESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWTQPPRNNWAYRLAQKLG 284
            .||||.|::|||||||||.|...|.|||.|:.|.|:||..||..|.|...  |.|......|...
  Rat   207 NFGGDPNSVTLFGESAGGESVSVLVLSPLTKNLFHRAISESGVALTPCLF--RENTRLAAEQVAI 269

  Fly   285 YTG--DNKDKAIFEFLRSMSGGEIVKAT------ATVLSNDEKHHRILFAFGPVVEPYTT---EH 338
            .||  ......|...||..:..|::..|      |..|..|.:..          .|:.|   :.
  Rat   270 ATGCAATTSADIVRCLREKTEEELLATTLKMKFFALDLHGDPRES----------YPFLTTVIDG 324

  Fly   339 TVVAKQPHELMQNSWSHRIPMMFGGTSFEGLLFYPEVSRRP---ATLDEVGNCKNLLPS----DL 396
            .::.|.|.|::.....:.:|.:.|....|...|.|.:...|   :.||:......|..|    ::
  Rat   325 VLLPKAPEEILSEKNFNTVPYIVGINKQEFGWFIPTMMGYPLSESKLDQKTATSLLWKSYPLTNI 389

  Fly   397 GLNLDPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQSSAPTYLY 461
            ...|.|...|.        |.|...|.......||::.....|..|....|... |.:.|.||:|
  Rat   390 SKELTPVATEK--------YLGGSDCPDKKKDLFLDMMGDVLFAVPSVIVARYH-RDARATTYVY 445

  Fly   462 RFDHDSKLCNAIR--IVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVDVWTSFA 524
            .|.:.....:.:|  .|:..       |||::..::.:....:.|.:. |..:.|.|:..|.:||
  Rat   446 EFKYHPSFVSDMRPKTVIAD-------HGDEVYSVWGTPFLKEGASEE-EINLSTMMMKFWGNFA 502

  Fly   525 AHGDPNCESI 534
            .:|:||.|.:
  Rat   503 RNGNPNGEGL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	161/530 (30%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	69/148 (47%)
Ces1a	NP_001177304.1	COesterase	24..545	CDD:278561	161/530 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336532
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.740