DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment alpha-Est10 and Bche

DIOPT Version :9

Sequence 1:	NP_001246962.1	Gene:	alpha-Est10 / 40896	FlyBaseID:	FBgn0015569	Length:	581	Species:	Drosophila melanogaster
Sequence 2:	NP_075231.1	Gene:	Bche / 65036	RGDID:	619996	Length:	597	Species:	Rattus norvegicus

Alignment Length:	582	Identity:	175/582 - (30%)
Similarity:	260/582 - (44%)	Gaps:	115/582 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 VIKTKSGPVRGVKRNTIWGGSYFSFEKIPFAKPPVGDLRFKAPEAVEPWDQELDCTSPADKPLQT 114
            :|.||:|.|||:.. .|.||:..:|..||:|:||:|.||||.|:.:..|....:.|..|:...|.
  Rat    28 IITTKTGRVRGLSM-PILGGTVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDVYNATKYANSCYQN 91

  Fly   115 -HMFFRKYAG----------SEDCLYLNVYVKDLQPDKLRPVMVWIYGGGYQVGEASRDMYSPDF 168
             ...|..:.|          |||||||||::...:| |...||||:||||:|.|.:|..:|...|
  Rat    92 IDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIPVPKP-KNATVMVWVYGGGFQTGTSSLPVYDGKF 155

  Fly   169 FMSKD-VVIVTVAYRLGALGFLSLDDPQLNVPGNAGLKDQIMALRWVQQNIEAFGGDSNNITLFG 232
            ....: |::|::.||:||||||:... ....|||.||.||.:||:|:|:||.||||:..::||||
  Rat   156 LTRVERVIVVSMNYRVGALGFLAFPG-NSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFG 219

  Fly   233 ESAGGASTHFLALSPQTEGLIHKAIVMSGSVLCPWT----QPPRNNWAYRLAQKLGYTGDNKDKA 293
            ||||.||.....|.||:..|..:||:.|||...||.    :..||. ...||:.:|.:.:| :|.
  Rat   220 ESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNR-TLTLAKFIGCSKEN-EKE 282

  Fly   294 IFEFLRSMSGGEIVKATATVLSNDEKHHRILFAFGPVVE-PYTTEHTVVAKQPHELMQNSWSHRI 357
            |...|||....||:.....||.:|....   ..|||.|: .:.|:      .||.|:|.......
  Rat   283 IITCLRSKDPQEILLNEKLVLPSDSIRS---INFGPTVDGDFLTD------MPHTLLQLGKVKTA 338

  Fly   358 PMMFG-----GTSF----------------------EGL-LFYPEVSR--RPATL----DEVGNC 388
            .::.|     ||:|                      ||| :::|.||.  :.|.|    |.:|:
  Rat   339 QILVGVNKDEGTAFLVYGAPGFSKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGD- 402

  Fly   389 KNLLPSDLGLNLDPKLRENYGLQLKKAYFGDEPCNQANMMKFLELCSYREFWHPIYRAALNRVRQ 453
                          :..|.|    ::|:  |:.....|:     :|...||........:|
  Rat   403 --------------QTPEVY----REAF--DDIIGDYNI-----ICPALEFTKKFAELEIN---- 438

  Fly   454 SSAPTYLYRFDHDSKLCNAIRIVLCGHQMRGVCHGDDLCYIFHSMLSHQSAPDSPEHKVITGMVD 518
                .:.|.|:|.|.       .|...:..||.||.::.::|...|..:......|......::.
  Rat   439 ----AFFYYFEHRSS-------KLPWPEWMGVMHGYEIEFVFGLPLERRVNYTRAEEIFSRSIMK 492

  Fly   519 VWTSFAAHGDPNCESIKSLKFAPIENVTNFKCLNIGDQ----FEVMALPELQKIEPVWNSFY 576
            .|.:||.:|.||.....|..: |:...|..|.|.:..:    ...:..|:.|    .|..|:
  Rat   493 TWANFAKYGHPNGTQGNSTVW-PVFTSTEQKYLTLNTEKSKINSKLRAPQCQ----FWRLFF 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
alpha-Est10	NP_001246962.1	COesterase	49..542	CDD:278561	167/542 (31%)
alpha-Est10	NP_001246962.1	Aes	<132..>279	CDD:223730	66/151 (44%)
Bche	NP_075231.1	COesterase	21..545	CDD:278561	173/576 (30%)
		Aes	<120..>272	CDD:223730	68/154 (44%)
		AChE_tetra	560..594	CDD:285837
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910